{"doi":"10.1101/2020.11.11.378729","title":"Common rules underlying optogenetic and behavioral modulation of responses in multi-cell-type V1 circuits","abstract":"Abstract The visual cortex receives non-sensory inputs containing behavioral and brain state information. Here we propose a parallel between optogenetic and behavioral modulations of activity and characterize their impact on cell-type-specific V1 processing under a common theoretical framework. We infer cell-type-specific circuitry from large-scale V1 recordings and demonstrate that, given strong recurrent excitation, the cell-type-specific responses imply key aspects of the known connectivity. In the inferred models, parvalbumin-expressing (PV), but not other, interneurons have responses to perturbations that we show theoretically imply that their activity stabilizes the circuit. We infer inputs that explain locomotion-induced changes in firing rates and find that, contrary to hypotheses of simple disinhibition, locomotory drive to VIP cells and to SOM cells largely cancel, with enhancement of excitatory-cell visual responses likely due to direct locomotory drive to them. We show that this SOM/VIP cancellation is a property emerging from V1 connectivity structure.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119135,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9454,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":553559,"name":"Francesco Fumarola","orcid":"0000-0002-2123-6413","position":1,"is_corresponding":false},{"id":553560,"name":"Daniel P. Mossing","orcid":"0000-0002-9939-4788","position":2,"is_corresponding":false},{"id":553561,"name":"Nataliya Kraynyukova","orcid":"0000-0002-2773-9820","position":3,"is_corresponding":false},{"id":542596,"name":"Hillel Adesnik","orcid":"0000-0002-3796-8643","position":4,"is_corresponding":false},{"id":255261,"name":"Kenneth D. Miller","orcid":"0000-0002-1433-0647","position":5,"is_corresponding":false},{"id":553558,"name":"Agostina Palmigiano","orcid":"0000-0002-1461-8405","position":0,"is_corresponding":true}],"reference_count":103,"raw_metadata":null,"created_at":"2026-07-18T23:14:08.313144Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}