{"doi":"10.1101/2020.11.11.376103","title":"A scale-free, fully connected global transition network underlies known microbiome diversity","abstract":"Abstract Microbiomes are inherently linked by their structural similarity, yet the global features of such similarity are not clear. Here we propose as solution a search-based microbiome transition network. By traversing a composition-similarity based network of 177,022 microbiomes, we show that although the compositions are distinct by habitat, each microbiome is on-average only seven neighbors from any other microbiome on Earth, indicating the inherent homology of microbiome at the global scale. This network is scale-free, suggesting a high degree of stability and robustness in microbiome transition. By tracking the minimum spanning tree in this network, a global roadmap of microbiome dispersal was derived that tracks the potential paths of formulating and propagating microbiome diversity. Such search-based global microbiome networks, reconstructed within hours on just one computing node, provide a readily expanded reference for tracing the origin and evolution of existing or new microbiomes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":123146,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9465,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":565795,"name":"Yufeng Zhang","orcid":"0000-0003-3531-8193","position":1,"is_corresponding":false},{"id":465469,"name":"Lu Liu","orcid":"0000-0002-4007-8414","position":2,"is_corresponding":false},{"id":85877,"name":"Zengbin Wang","orcid":"0000-0001-6464-7311","position":3,"is_corresponding":false},{"id":499251,"name":"Zheng Sun","orcid":"0000-0002-8537-8576","position":4,"is_corresponding":false},{"id":3554,"name":"Rob Knight","orcid":"0000-0002-0975-9019","position":5,"is_corresponding":false},{"id":85874,"name":"Xiaoquan Su","orcid":"0000-0003-2144-1991","position":6,"is_corresponding":false},{"id":499253,"name":"Jian Xu","orcid":"0000-0002-0548-8477","position":7,"is_corresponding":false},{"id":85875,"name":"Gongchao Jing","orcid":"0000-0001-5911-7615","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T23:14:59.547352Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}