{"doi":"10.1101/2020.11.08.20227884","title":"Host genetic liability for severe COVID-19 overlaps with alcohol drinking behavior and diabetic outcomes in over 1 million participants","abstract":"Abstract To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N>1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use, and alcohol use. COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors.","journal":"medRxiv","year":2020,"id":124212,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":568615,"name":"Antonella De Lillo","orcid":"0000-0003-0746-5209","position":1,"is_corresponding":false},{"id":432396,"name":"Gita A. Pathak","orcid":"0000-0003-3943-0895","position":2,"is_corresponding":false},{"id":567058,"name":"Flavio De Angelis","orcid":"0000-0002-4747-2385","position":3,"is_corresponding":false},{"id":569370,"name":"COVID-19 Host Genetics Initiative","orcid":null,"position":4,"is_corresponding":false},{"id":229994,"name":"Renato Polimanti","orcid":"0000-0003-0745-6046","position":5,"is_corresponding":false},{"id":230694,"name":"Frank R. Wendt","orcid":"0000-0002-2108-6822","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:07.789881Z","pmid":"33200138","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}