{"doi":"10.1101/2020.11.07.368720","title":"Non-Canonical Odor Coding in the Mosquito","abstract":"SUMMARY Female Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including dengue and yellow fever when they bite us to obtain a blood meal. Mosquitoes are intensely attracted to human-emitted body odor, heat, and carbon dioxide, which they detect using three different large multi-gene families encoding odor-gated ion channels. Genetic mutations that cause profound disruptions to the olfactory system have modest effects on human attraction, suggesting significant redundancy in odor coding. The canonical view is that olfactory sensory neurons each express a single chemosensory receptor that defines its ligand selectivity. Using immunostaining, RNA in situ hybridization, and single nucleus RNA sequencing, we discovered that Aedes aegypti uses an entirely different organizational principle, with many neurons co-expressing multiple chemosensory receptor genes. In vivo electrophysiology demonstrates that the broad ligand-sensitivity of mosquito olfactory neurons is due to this non-canonical co-expression. The redundancy afforded by an olfactory system in which many neurons co-express multiple receptors with different chemical sensitivity may greatly increase the robustness of the mosquito olfactory system and explain our longstanding inability to engineer new compounds that disrupt the detection of human body odor by mosquitoes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":118724,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":551911,"name":"Margaret Herre","orcid":"0000-0001-7868-3321","position":1,"is_corresponding":false},{"id":551912,"name":"Olivia V. Goldman","orcid":"0000-0001-9339-347X","position":2,"is_corresponding":false},{"id":551913,"name":"Tzu‐Chiao Lu","orcid":"0000-0001-9942-2307","position":3,"is_corresponding":false},{"id":551914,"name":"Gabriela Caballero-Vidal","orcid":"0000-0002-7725-6472","position":4,"is_corresponding":false},{"id":551915,"name":"Yanyan Qi","orcid":"0000-0003-0537-1540","position":5,"is_corresponding":false},{"id":551916,"name":"Zachary N. Gilbert","orcid":"0000-0002-5938-1595","position":6,"is_corresponding":false},{"id":551917,"name":"Zhongyan Gong","orcid":"0000-0003-1167-6287","position":7,"is_corresponding":false},{"id":551918,"name":"Takeshi Morita","orcid":"0000-0002-8570-6744","position":8,"is_corresponding":false},{"id":551919,"name":"Saher Rahiel","orcid":"0000-0003-2839-3443","position":9,"is_corresponding":false},{"id":551920,"name":"Majid Ghaninia","orcid":"0000-0001-7243-8851","position":10,"is_corresponding":false},{"id":551921,"name":"Rickard Ignell","orcid":"0000-0002-4607-5986","position":11,"is_corresponding":false},{"id":267006,"name":"Benjamin J. Matthews","orcid":"0000-0002-8697-699X","position":12,"is_corresponding":false},{"id":242235,"name":"Hongjie Li","orcid":"0000-0002-7332-7122","position":13,"is_corresponding":false},{"id":267007,"name":"Leslie B. Vosshall","orcid":"0000-0002-6060-8099","position":14,"is_corresponding":false},{"id":551910,"name":"Meg A. Younger","orcid":"0000-0003-4967-7939","position":0,"is_corresponding":true}],"reference_count":143,"raw_metadata":null,"created_at":"2026-07-18T23:14:03.409507Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}