{"doi":"10.1101/2020.11.06.371625","title":"The role of directionality in determining spatiotemporal tau pathology differs between AD-Like and Non-AD-Like mouse models","abstract":"ABSTRACT Introduction Current research indicates divergent spatiotemporal tauopathy progression between conditions and implicates transsynaptic connectome-based spread as a main mechanism. We examine tauopathy and connectome interactions to investigate why different spatiotemporal patterns of pathology arise. Methods We test whether divergent spatiotemporal tau pathology patterns from 15 mouse-model datasets can be explained by a directional bias in tau transmission along fiber tracts via a mathematical model called Directed Network Transmission (DNT). Results Amyloid-comorbid tauopathic mouse models meant to mimic AD demonstrate spatiotemporal tauopathy patterns consistent with retrograde direction spread biases. Non-amyloid-comorbid mice demonstrate no consistent spread biases. Further, canonically ‘early’ tau pathology regions in AD are implicated as having earliest pathology in a simulation with random tauopathy seeding locations with retrograde biased spread. Discussion These results implicate directional biases in tau pathology spread along fiber tracts as a strong candidate explanation for divergent spatiotemporal tau progression between conditions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":121804,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":305175,"name":"Ashish Raj","orcid":"0000-0003-2414-2444","position":1,"is_corresponding":false},{"id":559210,"name":"Christopher Mezias","orcid":"0000-0002-2730-8078","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T23:14:46.979435Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}