{"doi":"10.1101/2020.11.04.361154","title":"Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets","abstract":"Containment of the COVID-19 pandemic requires reducing viral transmission. SARS-CoV-2 infection is initiated by membrane fusion between the viral and host cell membranes, mediated by the viral spike protein. We have designed a dimeric lipopeptide fusion inhibitor that blocks this critical first step of infection for emerging coronaviruses and document that it completely prevents SARS-CoV-2 infection in ferrets. Daily intranasal administration to ferrets completely prevented SARS-CoV-2 direct-contact transmission during 24-hour co-housing with infected animals, under stringent conditions that resulted in infection of 100% of untreated animals. These lipopeptides are highly stable and non-toxic and thus readily translate into a safe and effective intranasal prophylactic approach to reduce transmission of SARS-CoV-2. ONE-SENTENCE SUMMARY: .","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119051,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107140,"name":"Katharina S. Schmitz","orcid":"0000-0002-8537-0646","position":1,"is_corresponding":false},{"id":225930,"name":"Francesca T. Bovier","orcid":"0000-0003-3446-9619","position":2,"is_corresponding":false},{"id":552805,"name":"Danny Noack","orcid":"0000-0003-1845-7511","position":3,"is_corresponding":false},{"id":70955,"name":"Bart L Haagmans","orcid":"0000-0001-6221-2015","position":4,"is_corresponding":false},{"id":552806,"name":"Sudipta Biswas","orcid":"0000-0001-7439-4952","position":5,"is_corresponding":false},{"id":218432,"name":"Barry Rockx","orcid":"0000-0003-2463-027X","position":6,"is_corresponding":false},{"id":294605,"name":"Samuel H. Gellman","orcid":"0000-0001-5617-0058","position":7,"is_corresponding":false},{"id":395046,"name":"Christopher A. Alabi","orcid":"0000-0003-2654-018X","position":8,"is_corresponding":false},{"id":107148,"name":"Rik L. de Swart","orcid":"0000-0003-3599-8969","position":9,"is_corresponding":false},{"id":225939,"name":"Anne Moscona","orcid":"0000-0002-1796-8320","position":10,"is_corresponding":false},{"id":225940,"name":"Matteo Porotto","orcid":"0000-0003-3866-9220","position":11,"is_corresponding":false},{"id":107149,"name":"Rory D. de Vries","orcid":"0000-0003-2817-0127","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-18T23:14:03.409507Z","pmid":"33173865","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}