{"doi":"10.1101/2020.10.28.20221804","title":"A catalog of associations between rare coding variants and COVID-19 outcomes","abstract":"Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19), a respiratory illness that can result in hospitalization or death. We investigated associations between rare genetic variants and seven COVID-19 outcomes in 543,213 individuals, including 8,248 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome-wide or when specifically focusing on (i) 14 interferon pathway genes in which rare deleterious variants have been reported in severe COVID-19 patients; (ii) 167 genes located in COVID-19 GWAS risk loci; or (iii) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, with results publicly browsable at https://rgc-covid19.regeneron.com.","journal":"medRxiv","year":2020,"id":119021,"datarank":1.2938114091853277,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.7739510237653686,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.7739510237653686,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":20,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":271380,"name":"Julie Horowitz","orcid":"0000-0002-8093-4182","position":1,"is_corresponding":false},{"id":552184,"name":"Nilanjana Banerjee","orcid":"0000-0001-8022-8598","position":2,"is_corresponding":false},{"id":553149,"name":"Rouel Lanche","orcid":null,"position":3,"is_corresponding":false},{"id":61925,"name":"Anthony Marcketta","orcid":"0000-0001-6356-3343","position":4,"is_corresponding":false},{"id":327046,"name":"Evan K. 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