{"doi":"10.1101/2020.10.16.342220","title":"The molecular and metabolic program for adaptation of white adipocytes to cool physiologic temperatures","abstract":"ABSTRACT Although visceral adipocytes located within the body’s central core are maintained at ~37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell, and generally exist at cooler temperatures. Responses of brown and beige/brite adipocytes to cold stress are well-studied; however, comparatively little is known about mechanisms by white adipocytes adapt to temperatures below 37°C. Here we report that adaptation of cultured adipocytes to 31°C, the temperature at which distal marrow adipose tissues and subcutaneous adipose tissues often reside, induces extensive changes in gene expression, increased anabolic and catabolic lipid metabolism, and elevated oxygen consumption with reduced reliance on glucose and preferential use of pyruvate, glutamine and fatty acids as energy sources. Cool temperatures up-regulate stearoyl-CoA desaturase-1 expression and monounsaturated lipid levels in cultured adipocytes and distal bone marrow adipose tissues, and stearoyl-CoA desaturase-1 activity is required for acquisition of maximal oxygen consumption at 31°C.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":127518,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":415150,"name":"Colleen E. Dugan","orcid":null,"position":1,"is_corresponding":false},{"id":277955,"name":"Akira Nishii","orcid":"0000-0002-8981-3264","position":2,"is_corresponding":false},{"id":576793,"name":"Ameena Benchamana","orcid":null,"position":3,"is_corresponding":false},{"id":277956,"name":"Ziru Li","orcid":"0000-0002-2755-9299","position":4,"is_corresponding":false},{"id":576368,"name":"Thomas S. Cadenhead","orcid":"0000-0002-5898-1652","position":5,"is_corresponding":false},{"id":301094,"name":"Arun K. Das","orcid":"0000-0002-0883-1816","position":6,"is_corresponding":false},{"id":235324,"name":"Charles R. Evans","orcid":"0000-0001-6698-5330","position":7,"is_corresponding":false},{"id":109551,"name":"Katherine A. Overmyer","orcid":"0000-0002-1929-1229","position":8,"is_corresponding":false},{"id":433335,"name":"Steven M. Romanelli","orcid":null,"position":9,"is_corresponding":false},{"id":576369,"name":"Sydney K. Peterson","orcid":"0000-0003-0773-2477","position":10,"is_corresponding":false},{"id":277954,"name":"Devika P. Bagchi","orcid":"0000-0002-2258-2289","position":11,"is_corresponding":false},{"id":277957,"name":"Callie A.S. Corsa","orcid":"0000-0002-3169-0281","position":12,"is_corresponding":false},{"id":279975,"name":"Julie Hardij","orcid":null,"position":13,"is_corresponding":false},{"id":277959,"name":"Brian S. Learman","orcid":"0000-0003-3680-0061","position":14,"is_corresponding":false},{"id":576794,"name":"Mahmoud El Azzouny","orcid":null,"position":15,"is_corresponding":false},{"id":498067,"name":"Ken Inoki","orcid":"0000-0001-8882-444X","position":16,"is_corresponding":false},{"id":247003,"name":"Ormond A. MacDougald","orcid":"0000-0001-6907-7960","position":17,"is_corresponding":false},{"id":576367,"name":"Hiroyuki Mori","orcid":"0000-0003-0503-3277","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T23:15:30.930746Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}