{"doi":"10.1101/2020.10.10.334755","title":"Flexible and transparent silver nanowire structures for multifunctional electrical and optical biointerfacing","abstract":"Abstract Transparent microelectrodes have recently emerged as a promising approach to combine electrophysiology with optophysiology for multifunctional biointerfacing. High-performance flexible platforms that allow seamless integration with soft tissue systems for such applications are urgently needed. Here, silver nanowires (Ag NWs)-based transparent microelectrodes and interconnects are designed to meet this demand. The Ag NWs percolating networks are patterned on flexible polymer substrates using an innovative photolithography-based solution-processing technique. The resulting nanowire networks exhibit a high average optical transparency of 76.1-90.0% over the visible spectrum, low normalized electrochemical impedance of 3.4-15 Ω cm 2 at 1 kHz which is even better than those of opaque solid Ag films, superior sheet resistance of 11-25 Ω sq −1 , excellent mechanical stability up to 10,000 bending cycles, good biocompatibility and chemical stability. Studies on Langendorff-perfused mouse and rat hearts demonstrate that the Ag NWs microelectrodes enable high-fidelity real-time monitoring of heart rhythm during co-localized optogenetic pacing and optical mapping with negligible light-induced electrical artifacts. This proof-of-concept work illustrates that the solution-processed, transparent, and flexible Ag NWs networks are a promising candidate for the next-generation of large-area multifunctional biointerfaces for interrogating complex biological systems in basic and translational research.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":127475,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9487,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":457909,"name":"Nicolas Boyajian","orcid":null,"position":1,"is_corresponding":false},{"id":576296,"name":"Zexu Lin","orcid":"0000-0002-4282-0686","position":2,"is_corresponding":false},{"id":456561,"name":"Rose T. Yin","orcid":"0000-0001-5887-9212","position":3,"is_corresponding":false},{"id":456560,"name":"Sofian N. Obaid","orcid":"0000-0001-8596-2994","position":4,"is_corresponding":false},{"id":456562,"name":"Jinbi Tian","orcid":"0000-0002-8684-2094","position":5,"is_corresponding":false},{"id":319037,"name":"Jaclyn A. Brennan","orcid":null,"position":6,"is_corresponding":false},{"id":456564,"name":"Sheena W. Chen","orcid":"0000-0002-8278-3517","position":7,"is_corresponding":false},{"id":457910,"name":"Alana N. Miniovich","orcid":null,"position":8,"is_corresponding":false},{"id":576297,"name":"Leqi Lin","orcid":"0000-0002-8944-2483","position":9,"is_corresponding":false},{"id":576298,"name":"Yarong Qi","orcid":"0000-0001-8732-2579","position":10,"is_corresponding":false},{"id":230525,"name":"Xitong Liu","orcid":"0000-0002-5197-3422","position":11,"is_corresponding":false},{"id":317055,"name":"Igor R. Efimov","orcid":"0000-0002-1483-5039","position":12,"is_corresponding":false},{"id":456566,"name":"Luyao Lu","orcid":"0000-0002-8784-2854","position":13,"is_corresponding":false},{"id":456563,"name":"Zhiyuan Chen","orcid":"0000-0001-6837-981X","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T23:15:30.930746Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}