{"doi":"10.1101/2020.10.09.333815","title":"Fetal innate immunity contributes to the induction of atypical behaviors in a mouse model of maternal immune activation","abstract":"Summary Maternal immune activation (MIA) increases likelihood of altered neurodevelopmental outcomes. Maternal cytokines are proposed to affect fetal brain development in mice; however, the contribution of fetal immunity to neurodevelopmental disorders is largely unexplored. Here, we show that MIA mediated by Toll-like receptor 3 (TLR3), but not other TLRs, induces a specific set of behavioral phenotypes including decreased sociability and increased restricted repetitive behavior in offspring. Accordingly, these behavioral phenotypes were absent when offspring were deficient for Trif , the downstream adapter molecule of TLR3. Using single-cell RNA sequencing, we identified clusters of border-associated macrophages that were significantly enriched in the fetal brain following TLR3-MIA, and these clusters were diminished in Trif −/− fetal brains.Moreover, we found that triggering TLR3-TRIF in offspring can occur through transplacental viral infection, resulting in altered behavioral phenotypes. Collectively, our data indicate that fetal innate immunity contributes to MIA-induced atypical behaviors in mice.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":127465,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9569,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":576751,"name":"Hsiu‐Chun Chuang","orcid":null,"position":1,"is_corresponding":false},{"id":576265,"name":"Matthew Davis","orcid":"0000-0001-5125-1561","position":2,"is_corresponding":false},{"id":513523,"name":"Kristina Geiger","orcid":"0000-0001-6738-7439","position":3,"is_corresponding":false},{"id":228435,"name":"Rick Z. Li","orcid":"0000-0001-8518-5793","position":4,"is_corresponding":false},{"id":485195,"name":"Madeline L. Arnold","orcid":"0000-0003-0130-4789","position":5,"is_corresponding":false},{"id":576752,"name":"Patrick M. Lin","orcid":null,"position":6,"is_corresponding":false},{"id":576753,"name":"Rhea Misra","orcid":null,"position":7,"is_corresponding":false},{"id":561536,"name":"Laurent Coscoy","orcid":"0000-0002-7337-2345","position":8,"is_corresponding":false},{"id":572895,"name":"Kaoru Saijo","orcid":"0000-0003-1656-1753","position":9,"is_corresponding":false},{"id":560162,"name":"Eva K. Nichols","orcid":"0000-0002-8501-8028","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-18T23:15:30.930746Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}