{"doi":"10.1101/2020.10.06.20207753","title":"Trans-ethnic genome-wide meta-analysis of 35,732 cases and 34,424 controls identifies novel genomic cross-ancestry loci contributing to lung cancer susceptibility","abstract":"Summary Lung cancer is the leading cause of cancer death worldwide. Genome-wide association studies have revealed genetic risk factors, highlighting the role of smoking, family history, telomere regulation, and DNA damage-repair in lung cancer etiology. Many studies have focused on a single ethnic group to avoid confounding from variability in allele frequencies across populations; however, comprehensive multi-ethnic analyses may identify variants that are more likely to be causal. This large-scale, multi- ethnic meta-analyses identified 28 novel risk loci achieving genome-wide significance. Leading candidates were further studied using single-cell methods for evaluating DNA-damage. DNA-damage promoting activities were confirmed for selected genes by knockdown genes and overexpression studies.","journal":"medRxiv","year":2020,"id":124097,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9417,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":97260,"name":"Younghun Han","orcid":"0000-0001-5048-8479","position":1,"is_corresponding":false},{"id":15497,"name":"Yafang Li","orcid":"0000-0002-1645-1995","position":2,"is_corresponding":false},{"id":568363,"name":"Jun Xia","orcid":"0000-0001-7331-0673","position":3,"is_corresponding":false},{"id":15498,"name":"Xiangjun Xiao","orcid":null,"position":4,"is_corresponding":false},{"id":235843,"name":"Ryan Sun","orcid":"0000-0003-1176-1561","position":5,"is_corresponding":false},{"id":338823,"name":"Kyle M. 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