{"doi":"10.1101/2020.10.01.322578","title":"A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria","abstract":"Abstract Bacterial cell division is driven by the polymerization of the GTPase FtsZ into a contractile structure, the so-called Z-ring. This essential process involves proteins that modulate FtsZ dynamics and hence the overall Z-ring architecture. Actinobacteria, like Streptomyces and Mycobacterium lack known key FtsZ-regulators. Here we report the identification of SepH, a conserved actinobacterial protein that directly regulates FtsZ dynamics. We show that SepH is crucially involved in cell division in Streptomyces and that it binds FtsZ via a conserved helix-turn-helix motif, stimulating the assembly of FtsZ protofilaments. Comparative in vitro studies using the SepH homolog from Mycobacterium further reveal that SepH can also bundle FtsZ protofilaments, indicating an additional Z-ring stabilizing function in vivo . We propose that SepH plays a crucial role at the onset of cytokinesis in actinobacteria by promoting the rapid assembly of FtsZ filaments into division-competent Z-rings that can go on to mediate septum synthesis.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":125429,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":571452,"name":"Matthew J. Bush","orcid":"0000-0001-8216-0152","position":1,"is_corresponding":false},{"id":571453,"name":"Joseph W. Sallmen","orcid":"0000-0002-5041-299X","position":2,"is_corresponding":false},{"id":571454,"name":"Govind Chandra","orcid":"0000-0002-7882-6676","position":3,"is_corresponding":false},{"id":571455,"name":"J. Steven Richardson","orcid":"0000-0003-2573-2227","position":4,"is_corresponding":false},{"id":571456,"name":"Kim Findlay","orcid":"0000-0002-1556-0532","position":5,"is_corresponding":false},{"id":571457,"name":"Joseph R. McCormick","orcid":"0000-0002-9071-7296","position":6,"is_corresponding":false},{"id":571458,"name":"Susan Schlimpert","orcid":"0000-0001-6364-8056","position":7,"is_corresponding":false},{"id":571451,"name":"Félix Ramos‐León","orcid":"0000-0002-7192-9111","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:15.482227Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}