{"doi":"10.1101/2020.09.30.317628","title":"Epithelial HVEM promotes basement membrane synthesis and intraepithelial T cell survival and migration","abstract":"Summary Intraepithelial T cells (IET) provide continuous surveillance of the intestinal epithelium, but little was known about how epithelial-derived signals regulate the IET population. We show that epithelial expression of the herpes virus entry mediator (HVEM), a member of the TNF receptor superfamily (TNFRSF), maintained the survival of small intestine IET, especially innate-like TCRαβ + cells lacking CD4 and CD8β. Patrolling movement of all CD8α + IET also was impaired in the absence of HVEM. HVEM-deficient epithelial cells exhibited downregulation of synthesis of basement membrane components, including collagen IV. Collagen IV supported IET survival in vitro via interactions with β 1 integrins expressed by the IET; absence of β 1 integrins decreased some IET subsets. Therefore, these data define a circuit whereby epithelial cells regulate intestine resident T lymphocyte populations through basement membrane synthesis.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":131157,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":584531,"name":"Qingyang Wang","orcid":"0000-0002-9999-3019","position":1,"is_corresponding":false},{"id":349148,"name":"Goo‐Young Seo","orcid":null,"position":2,"is_corresponding":false},{"id":584532,"name":"Jr‐Wen Shui","orcid":"0000-0002-5243-3727","position":3,"is_corresponding":false},{"id":273867,"name":"Zbigniew Mikulski","orcid":"0000-0002-1918-9216","position":4,"is_corresponding":false},{"id":585097,"name":"Paola Marcovecchio","orcid":null,"position":5,"is_corresponding":false},{"id":584533,"name":"Masumi Takahashi","orcid":"0000-0002-8636-9321","position":6,"is_corresponding":false},{"id":584534,"name":"Charles D. Surh","orcid":"0000-0002-1401-3684","position":7,"is_corresponding":false},{"id":584535,"name":"Hilde Cheroutre","orcid":"0000-0002-3669-2964","position":8,"is_corresponding":false},{"id":266586,"name":"Mitchell Kronenberg","orcid":"0000-0001-6318-6445","position":9,"is_corresponding":false},{"id":584530,"name":"Daisuke Takahashi","orcid":"0000-0003-3222-6648","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-18T23:16:00.235845Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}