{"doi":"10.1101/2020.09.27.20202655","title":"Assessment of Commercial SARS-CoV-2 Antibody Assays, Jamaica","abstract":"Abstract The performance of the Roche Elecsys ® Anti-SARS-CoV-2, Abbott Architect SARS-CoV-2 IgG, Euroimmun SARS-CoV-2 IgA, Euroimmun SARS-CoV-2 IgG ELISA, and Trillium IgG/IgM rapid assays was evaluated in Jamaica, the largest country of the English-speaking Caribbean. Diagnostic sensitivities of the assays were assessed by testing serum samples from SARS-CoV-2 PCR-confirmed persons. Serum samples collected ≥14 days after onset of symptoms, or ≥14 days after an initial SARS-CoV-2 RT-PCR positive test for asymptomatics, showed diagnostic sensitivities ranging from 67.9-75.0% when including all possible disease severities and increased to 90.0-95.0% when examining those with moderate to critical disease. Grouping moderate to critical disease showed a significant association with a SARS-CoV-2 antibody positive result for all assays. Diagnostic specificity, assessed by testing serum samples collected during 2018-2019 from healthy persons and from persons with antibodies to a wide range of viral infections, ranged from 96.7-100.0%. For all assays examined, SARS-CoV-2 real-time PCR cycle threshold (Ct) values of the initial nasopharyngeal swab sample testing positive were significantly different for samples testing antibody positive versus negative. These data from a predominantly African descent Caribbean population shows comparable diagnostic sensitivities and specificities for all testing platforms assessed and limited utility of these tests for persons with asymptomatic and mild infections.","journal":"medRxiv","year":2020,"id":124329,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":569460,"name":"Alrica Bruce-Mowatt","orcid":null,"position":1,"is_corresponding":false},{"id":568903,"name":"Yakima Z.R. Phillips","orcid":"0000-0003-3199-4389","position":2,"is_corresponding":false},{"id":511259,"name":"Nicole Brown","orcid":"0000-0002-3184-0550","position":3,"is_corresponding":false},{"id":569461,"name":"Keisha Francis","orcid":null,"position":4,"is_corresponding":false},{"id":568904,"name":"Jabari Brown","orcid":"0000-0001-8528-5700","position":5,"is_corresponding":false},{"id":568905,"name":"Devon K. Taylor","orcid":"0000-0002-8605-9550","position":6,"is_corresponding":false},{"id":568906,"name":"Carl A. Bruce","orcid":"0000-0002-6639-946X","position":7,"is_corresponding":false},{"id":568907,"name":"Donovan McGrowder","orcid":"0000-0001-8018-7722","position":8,"is_corresponding":false},{"id":568908,"name":"Gilian Wharfe","orcid":"0000-0003-3842-5787","position":9,"is_corresponding":false},{"id":568909,"name":"Simone L. Sandiford","orcid":"0000-0003-2368-0902","position":10,"is_corresponding":false},{"id":568910,"name":"Tamara Thompson","orcid":"0000-0003-1180-3231","position":11,"is_corresponding":false},{"id":568911,"name":"Joshua J. Anzinger","orcid":"0000-0002-4541-4683","position":12,"is_corresponding":false},{"id":568902,"name":"Tiffany R. Butterfield","orcid":"0000-0001-8474-0046","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-18T23:15:07.789881Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}