{"doi":"10.1101/2020.09.25.308734","title":"CARD8 inflammasome mediates pyroptosis of HIV-1-infected cells by sensing viral protease activity","abstract":"Abstract HIV-1 has high mutation rates and exists as mutant swarms in the host. Rapid evolution of HIV-1 allows the virus to outpace host immune system, leading to viral persistence. Novel approaches to target immutable components are needed to clear HIV-1 infection. Here we report a pattern-recognition receptor CARD8 that senses enzymatic activity of the HIV-1 protease, which is indispensable for the virus. All subtypes of HIV-1 can be sensed by CARD8 despite substantial viral diversity. HIV-1 evades CARD8 sensing because the viral protease remains inactive in infected cells prior to viral budding. Induction of premature intracellular activation of the viral protease triggers CARD8 inflammasome-mediated pyroptosis of HIV-1-infected cells. This strategy leads to clearance of latent HIV-1 in patient CD4 + T cells after virus reactivation. Taken together, our study identifies CARD8 as an inflammasome sensor of HIV-1 that holds promise as a strategy for clearance of persistent HIV-1 infection.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":127393,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":576120,"name":"Hongbo Gao","orcid":"0000-0003-2013-5298","position":1,"is_corresponding":false},{"id":576121,"name":"Kolin M. Clark","orcid":"0000-0003-3025-125X","position":2,"is_corresponding":false},{"id":576681,"name":"Tang Pengfei","orcid":null,"position":3,"is_corresponding":false},{"id":576122,"name":"Gray H. Harlan","orcid":"0000-0002-5235-2644","position":4,"is_corresponding":false},{"id":324222,"name":"Sebla B. Kutluay","orcid":"0000-0001-5549-7032","position":5,"is_corresponding":false},{"id":227903,"name":"Carl J. DeSelm","orcid":"0000-0001-7645-5798","position":6,"is_corresponding":false},{"id":552303,"name":"Rachel M. Presti","orcid":"0000-0002-5469-0727","position":7,"is_corresponding":false},{"id":413853,"name":"Liang Shan","orcid":"0000-0002-8833-2514","position":8,"is_corresponding":false},{"id":576119,"name":"Qiankun Wang","orcid":"0000-0003-3508-960X","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T23:15:30.930746Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}