{"doi":"10.1101/2020.09.23.310276","title":"NIAGADS Alzheimer’s GenomicsDB: A resource for exploring Alzheimer’s Disease genetic and genomic knowledge","abstract":"Abstract INTRODUCTION The NIAGADS Alzheimer’s Genomics Database (GenomicsDB) is a public knowledgebase of Alzheimer’s disease (AD) genetic datasets and genomic annotations. METHODS It uses a custom systems architecture to adopt and enforce rigorous standards that facilitate harmonization of AD-relevant GWAS summary statistics datasets with functional annotations, including a database of >230 million annotated variants from the AD Sequencing Project’s joint-calling efforts. RESULTS The knowledgebase generates genome browser tracks and interactive compiled from harmonized datasets and annotations in the underlying database. These facilitate data sharing and discovery, by contextualizing AD-risk associations in a broader functional genomic context or summarizing them in the context of functionally annotated genes and variants. DISCUSSION Created to make AD-genetics knowledge more accessible to AD-researchers, the GenomicsDB shares annotated AD-relevant summary statistics datasets via a web interface designed to guide users unfamiliar with genetic data in not only exploring, but also interpreting this ever-growing volume of data.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":124061,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":35.18991258606018,"corpus_rank":8206,"citation_count":3,"citer_count":2,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":60359,"name":"Otto Valladares","orcid":"0000-0001-8055-2187","position":1,"is_corresponding":false},{"id":568259,"name":"Pavel P. Kuksa","orcid":"0000-0003-2248-6403","position":2,"is_corresponding":false},{"id":569218,"name":"Prabhakaran Gangadharan","orcid":null,"position":3,"is_corresponding":false},{"id":568260,"name":"Wan‐Ping Lee","orcid":"0000-0002-5305-1181","position":4,"is_corresponding":false},{"id":568261,"name":"Jeffrey Cifello","orcid":"0009-0000-6147-2026","position":5,"is_corresponding":false},{"id":569219,"name":"Živadin Katanić","orcid":null,"position":6,"is_corresponding":false},{"id":568262,"name":"Amanda B Kuzma","orcid":"0000-0002-6064-5420","position":7,"is_corresponding":false},{"id":568263,"name":"Nicholas R. Wheeler","orcid":"0000-0003-2248-8919","position":8,"is_corresponding":false},{"id":261839,"name":"William S. Bush","orcid":"0000-0002-9729-6519","position":9,"is_corresponding":false},{"id":568264,"name":"Yuk Yee Leung","orcid":"0000-0002-3047-5440","position":10,"is_corresponding":false},{"id":27607,"name":"Gerard D. Schellenberg","orcid":"0000-0003-1115-2475","position":11,"is_corresponding":false},{"id":6393,"name":"Christian J. Stoeckert","orcid":"0000-0002-5714-991X","position":12,"is_corresponding":false},{"id":261852,"name":"Li‐San Wang","orcid":"0000-0002-3684-0031","position":13,"is_corresponding":false},{"id":383487,"name":"Emily Greenfest‐Allen","orcid":"0000-0002-7294-8461","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-18T23:15:07.789881Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}