{"doi":"10.1101/2020.09.22.308221","title":"ADAR2 deaminase activity promotes Th17 effector function and protects against intestine inflammation","abstract":"SUMMARY ADAR1 and ADAR2 catalyze adenosine-to-inosine (A-to-I) editing, the most common post-transcriptional modification in RNA. While ADAR1 is ubiquitously expressed and plays a critical role in preventing activation of the host immune system, ADAR2 exhibits tissue-specific and inducible expression patterns, and its function in the immune system is not known. Here, we identify an intragenic super-enhancer involved in the dramatic induction of ADAR2 when naïve helper T cells differentiate toward the Th17 lineage. By editing the inverted repeat sequences at the 3’ untranslated region (UTR) of Malt1 , which encodes a component of the NF-κB activation complex, ADAR2 promotes MALT1 expression and Th17 effector function. Interference with the ADAR2-MALT1 pathway dampens the production of Th17 cytokines and promotes T cell-mediated colitis. This study expands our understanding of RNA editing in adaptive immunity and identifies the ADAR2-MALT1-IL-17A axis as a potential therapeutic target for inflammatory conditions in the intestine.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":125411,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9598,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":278249,"name":"Yajing Hao","orcid":"0000-0003-1384-4176","position":1,"is_corresponding":false},{"id":493041,"name":"Benjamin S. Cho","orcid":null,"position":2,"is_corresponding":false},{"id":571407,"name":"Nicholas Chen","orcid":"0000-0003-1919-9059","position":3,"is_corresponding":false},{"id":571408,"name":"Anna Zheng","orcid":"0000-0002-8431-6584","position":4,"is_corresponding":false},{"id":285515,"name":"Shuyang Zhang","orcid":"0000-0002-4592-4966","position":5,"is_corresponding":false},{"id":571409,"name":"Ge Sun","orcid":"0000-0003-4780-6047","position":6,"is_corresponding":false},{"id":492034,"name":"Parth Patel","orcid":"0000-0002-2248-7281","position":7,"is_corresponding":false},{"id":94638,"name":"Yuxin Li","orcid":"0000-0001-9739-9860","position":8,"is_corresponding":false},{"id":43217,"name":"Brian A. Yee","orcid":"0000-0001-5615-8550","position":9,"is_corresponding":false},{"id":43290,"name":"G Yeo","orcid":null,"position":10,"is_corresponding":false},{"id":106153,"name":"Bing Zhou","orcid":"0000-0003-2846-1813","position":11,"is_corresponding":false},{"id":43247,"name":"Xiang‐Dong Fu","orcid":"0000-0001-5499-8732","position":12,"is_corresponding":false},{"id":242484,"name":"Wendy Huang","orcid":"0000-0001-7425-8280","position":13,"is_corresponding":false},{"id":571406,"name":"Shengyun Ma","orcid":"0000-0003-3368-9388","position":0,"is_corresponding":true}],"reference_count":107,"raw_metadata":null,"created_at":"2026-07-18T23:15:15.482227Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}