{"doi":"10.1101/2020.09.20.305508","title":"Diesel2p mesoscope with dual independent scan engines for flexible capture of dynamics in distributed neural circuitry","abstract":"Abstract Imaging the activity of neurons that are widely distributed across brain regions deep in scattering tissue at high speed remains challenging. Here, we introduce an open-source system with Dual Independent Enhanced Scan Engines for Large Field-of-view Two-Photon imaging (Diesel2p). Combining novel optical design, adaptive optics, and temporal multiplexing, the system offers subcellular resolution over a large field-of-view (∼ 25 mm 2 ) with independent scan engines. We demonstrate the flexibility and various use cases of this system for calcium imaging of neurons in the living brain.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119046,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9457,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":552784,"name":"Jeffrey N. Stirman","orcid":"0000-0003-4761-3341","position":1,"is_corresponding":false},{"id":552785,"name":"Yiyi Yu","orcid":"0000-0003-1053-413X","position":2,"is_corresponding":false},{"id":552786,"name":"Riichiro Hira","orcid":"0000-0002-8719-4498","position":3,"is_corresponding":false},{"id":455457,"name":"Spencer L. Smith","orcid":"0000-0002-2021-7034","position":4,"is_corresponding":false},{"id":459730,"name":"Che‐Hang Yu","orcid":"0000-0002-0353-9752","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-18T23:14:03.409507Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}