{"doi":"10.1101/2020.09.17.20196790","title":"Mixed cytomegalovirus genotypes in HIV positive mothers show compartmentalization and distinct patterns of transmission to infants","abstract":"Abstract Cytomegalovirus (CMV) is the most congenital infection (cCMVi), and is particularly common among infants born to HIV-infected women. Studies of cCMVi pathogenesis are complicated by the presence of multiple infecting maternal CMV strains, especially in HIV-positive women, and the large, recombinant CMV genome. Using newly-developed tools to reconstruct CMV haplotypes, we demonstrate anatomic CMV compartmentalization in five HIV-infected mothers, and identify the possibility of congenitally-transmitted genotypes in three of their infants. A single CMV strain was transmitted in each congenitally-infected case, and all were closely related to those that predominate in the cognate maternal cervix. Compared to non-transmitted strains, these congenitally-transmitted CMV strains showed statistically significant similarities in 19 genes associated with tissue-tropism and immunomodulation. In all infants, incident superinfections with distinct strains from breast milk were captured during follow-up. The results represent potentially important new insights into the virologic determinants of early CMV infection.","journal":"medRxiv","year":2020,"id":125372,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9648,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":376370,"name":"Jennifer A. Slyker","orcid":"0000-0001-7095-8861","position":1,"is_corresponding":false},{"id":395918,"name":"Sunando Roy","orcid":"0000-0001-5968-9111","position":2,"is_corresponding":false},{"id":461290,"name":"Josephine M. Bryant","orcid":"0000-0002-0149-5768","position":3,"is_corresponding":false},{"id":571318,"name":"Claire Atkinson","orcid":"0009-0000-5182-4606","position":4,"is_corresponding":false},{"id":571319,"name":"Juliana Cudini","orcid":"0000-0002-8420-0362","position":5,"is_corresponding":false},{"id":289075,"name":"Carey Farquhar","orcid":"0000-0001-8575-3439","position":6,"is_corresponding":false},{"id":571320,"name":"Paul Griffiths","orcid":"0000-0001-9317-5915","position":7,"is_corresponding":false},{"id":366536,"name":"James Kiarie","orcid":"0000-0003-4180-7858","position":8,"is_corresponding":false},{"id":305627,"name":"Sofia Morfopoulou","orcid":"0000-0001-8181-4548","position":9,"is_corresponding":false},{"id":331199,"name":"Alison C. Roxby","orcid":"0000-0001-9449-8062","position":10,"is_corresponding":false},{"id":571983,"name":"Helena Tutil","orcid":null,"position":11,"is_corresponding":false},{"id":571321,"name":"Rachel Williams","orcid":"0000-0001-9069-6416","position":12,"is_corresponding":false},{"id":392192,"name":"Soren Gantt","orcid":"0000-0001-5743-3606","position":13,"is_corresponding":false},{"id":289015,"name":"Richard A. Goldstein","orcid":"0000-0001-5148-4672","position":14,"is_corresponding":false},{"id":289016,"name":"Judith Breuer","orcid":"0000-0001-8246-0534","position":15,"is_corresponding":false},{"id":571317,"name":"Juanita Pang","orcid":"0000-0002-4792-5903","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T23:15:15.482227Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}