{"doi":"10.1101/2020.09.12.294165","title":"Advanced Retinal Imaging and Ocular Parameters of the Rhesus Macaque Eye","abstract":"Abstract Purpose To determine the normal ocular biometric and perform advanced retinal imaging and functional assessment of a non-human primate used commonly in scientific research, the rhesus macaque. Methods We performed ocular phenotyping on rhesus macaques at the California National Primate Research Center. This consisted of anterior and posterior segment eye examination by ophthalmologists, advanced retinal imaging, and functional retinal electrophysiology. Results Full eye exams were performed on 142 animals consisting of pupillary light reflex, tonometry, external exam and photography, anterior slit lamp examination, and posterior segment examination by indirect ophthalmoscopy. Ages of the rhesus macaques ranged from 0.7 to 29 years (mean=16.4 years, stdev=7.5 years). Anterior segment measurements such as intraocular pressure (n=142), corneal thickness (n=84), lens thickness (n=114), and axial length (n=114) were acquired. Advanced retinal imaging in the form of fundus photography (n=78), optical coherence tomography (n=60), and quantitative autofluorescence (n=44) were obtained. Electroretinography (n=75) was used to assay retinal function. Quantitative analyses of macular structure, retinal layer segmentation, and rod and cone photoreceptor electrical responses are reported. Quantitative assessments were made and variations between genders and age groups were analyzed to compare with established sex and age-related changes in human eyes. Conclusions The rhesus macaque has ocular structure and function very similar to that of the human eye. Age-related ocular changes between rhesus and humans are similar. In particular, macular structure and function are very similar to humans making this species particularly useful for the study of macular biology and development of therapies for inherited and age-related macular degenerations as well as cone photoreceptor disorders.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":127353,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6262,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":446311,"name":"Tu M. Tran","orcid":null,"position":1,"is_corresponding":false},{"id":445256,"name":"Soo-Hyun Kim","orcid":"0000-0002-8247-1062","position":2,"is_corresponding":false},{"id":445258,"name":"Sangwan Park","orcid":"0000-0003-0381-0386","position":3,"is_corresponding":false},{"id":576660,"name":"J. Timothy Stout","orcid":null,"position":4,"is_corresponding":false},{"id":232106,"name":"Rui Chen","orcid":"0000-0002-4387-9735","position":5,"is_corresponding":false},{"id":246479,"name":"Jeffrey Rogers","orcid":"0000-0002-7374-6490","position":6,"is_corresponding":false},{"id":260772,"name":"Glenn Yiu","orcid":"0000-0003-3061-3310","position":7,"is_corresponding":false},{"id":246470,"name":"Sara M. Thomasy","orcid":"0000-0001-5617-9677","position":8,"is_corresponding":false},{"id":445260,"name":"Ala Moshiri","orcid":"0000-0002-4277-8094","position":9,"is_corresponding":false},{"id":445257,"name":"Kira H. Lin","orcid":"0000-0003-2034-9739","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T23:15:30.930746Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}