{"doi":"10.1101/2020.09.02.273649","title":"Dysregulation of hippocampal adult-born immature neurons disrupts a brain-wide network for spatial memory","abstract":"Summary Mounting evidence suggests that cognitive deficits associated with various neurological disorders may arise in part from a small population of dysregulated adult-born neurons in the dentate gyrus (DG). How these dysregulated adult-born neurons contribute to brain-wide network maladaptation and subsequent cognitive deficits remains unknown. Using an established mouse model with a small number of time-stamped dysregulated adult-born immature neurons and spatial memory deficits, we performed resting state functional magnetic resonance imaging and found that approximately 500 deficient immature neurons (<0.1% of total DG granule neurons) are sufficient to induce a significant decrease in the functional connectivity between DG and insular cortex (IC), two brain regions without direct anatomical connections. Furthermore, using a combination of rabies-based retrograde tracing and in vivo fiber photometry recording, we demonstrated that dysregulated adult-born neurons induce aberrant activity and synchrony in local hippocampal CA3 and CA1 regions, as well as distal medial-dorsal thalamus and IC regions during a spatial memory process. These results suggest that a few hundred dysregulated adult-born immature neurons can impact brain-wide network dynamics across several anatomically discrete regions and collectively contribute to impaired cognitive functions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":122977,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9368,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":557434,"name":"Zhiqiang Hu","orcid":"0000-0001-8854-3410","position":1,"is_corresponding":false},{"id":355381,"name":"Sung‐Ho Lee","orcid":"0000-0003-2111-5504","position":2,"is_corresponding":false},{"id":565592,"name":"Ramya Kolagani","orcid":null,"position":3,"is_corresponding":false},{"id":316833,"name":"Tzu-Hao Harry Chao","orcid":"0000-0002-0057-6849","position":4,"is_corresponding":false},{"id":290964,"name":"Yan‐Jia Luo","orcid":"0000-0002-1288-438X","position":5,"is_corresponding":false},{"id":318935,"name":"Woomi Ban","orcid":null,"position":6,"is_corresponding":false},{"id":12978,"name":"Heather A. Sullivan","orcid":"0000-0001-6668-9996","position":7,"is_corresponding":false},{"id":565593,"name":"Sergio Gamero-Alameda","orcid":null,"position":8,"is_corresponding":false},{"id":565030,"name":"Zane R. Lybrand","orcid":"0000-0003-1543-8155","position":9,"is_corresponding":false},{"id":565031,"name":"Yuguo Yu","orcid":"0000-0003-0603-2890","position":10,"is_corresponding":false},{"id":473321,"name":"Jenny Hsieh","orcid":"0000-0003-0214-0771","position":11,"is_corresponding":false},{"id":12976,"name":"Ian R. Wickersham","orcid":"0000-0003-0389-5324","position":12,"is_corresponding":false},{"id":38052,"name":"Steven E. Brenner","orcid":"0000-0001-7559-6185","position":13,"is_corresponding":false},{"id":271355,"name":"Yen‐Yu Ian Shih","orcid":"0000-0001-6529-911X","position":14,"is_corresponding":false},{"id":135505,"name":"Juan Song","orcid":"0000-0002-7836-343X","position":15,"is_corresponding":false},{"id":290963,"name":"Hechen Bao","orcid":"0000-0002-2768-0611","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T23:14:55.385653Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}