{"doi":"10.1101/2020.08.31.275313","title":"Daily rewiring of a neural circuit generates a predictive model of environmental light","abstract":"Ongoing sensations are compared to internal, experience-based, reference models; mismatch between reality and expectation can signal opportunity or danger, and can shape behavior. The nature of internal reference models is largely unknown. We describe a model that enables moment-to-moment luminance evaluation in flies. Abrupt shifts to lighting conditions inconsistent with the subjective time-of-day trigger locomotion, whereas shifts to appropriate conditions induce quiescence. The time-of-day prediction is generated by a slowly shifting activity balance between opposing neuronal populations, LNvs and DN1as. The two populations undergo structural changes in axon length that accord with, and are required for, conveying time-of-day information. Each day, in each population, the circadian clock directs cellular remodeling such that the maximum axonal length in one population coincides with the minimum in the other; preventing remodeling prevents transitioning between opposing internal states. We propose that a dynamic predictive model resides in the shifting connectivities of the LNv- DN1a circuit.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":130884,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":584099,"name":"Slater J. Sharp","orcid":null,"position":1,"is_corresponding":false},{"id":335333,"name":"Dragana Rogulja","orcid":"0000-0002-3535-8745","position":2,"is_corresponding":false},{"id":583706,"name":"Bryan J. Song","orcid":"0000-0003-0549-4823","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-18T23:15:56.698770Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}