{"doi":"10.1101/2020.08.23.263608","title":"Focal Electrical Stimulation of Human Retinal Ganglion Cells for Vision Restoration","abstract":"ABSTRACT Vision restoration with retinal implants that electrically stimulate retinal ganglion cells (RGCs), which transmit visual information to the brain, is limited by indiscriminate activation of many cells and cell types. Recent work in isolated macaque retina has demonstrated that direct electrical stimulation of RGCs can be performed with single-cell, single-spike resolution. However, the fidelity of epiretinal stimulation has not been examined in the human retina. Here, electrical activation of the major RGC types was examined using large-scale, multi-electrode recording and stimulation in the human retina ex vivo and compared directly to results from macaque. Targeted activation with single-cell, single-spike resolution was often possible without activating overlying axon bundles, at low stimulation current levels similar to those in macaque. Distinct cell types could be identified and targeted based on their distinct electrical signatures. Simulation based on these measurements revealed that a novel, dynamic stimulation approach would produce a nearly optimal evoked visual signal. These results indicate that high-fidelity control of spiking in human RGCs is achievable with extracellular stimulation and that the macaque retina is an accurate model for vision restoration with epiretinal implants.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":122253,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9451,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":563152,"name":"Alex Gogliettino","orcid":"0000-0003-4262-9395","position":1,"is_corresponding":false},{"id":563153,"name":"Moosa Zaidi","orcid":"0000-0003-1788-6306","position":2,"is_corresponding":false},{"id":563154,"name":"Gorish Aggarwal","orcid":"0000-0002-2469-7485","position":3,"is_corresponding":false},{"id":316886,"name":"Alexandra Kling","orcid":"0000-0002-5718-9313","position":4,"is_corresponding":false},{"id":316887,"name":"Nishal P. Shah","orcid":"0000-0002-1275-0381","position":5,"is_corresponding":false},{"id":563155,"name":"Ramandeep Vilkhu","orcid":"0000-0002-2104-4921","position":6,"is_corresponding":false},{"id":563156,"name":"Madeline Hays","orcid":"0000-0002-5841-0438","position":7,"is_corresponding":false},{"id":563157,"name":"Huy Nguyen","orcid":"0000-0002-3922-9203","position":8,"is_corresponding":false},{"id":563158,"name":"Victoria H. Fan","orcid":"0000-0002-4039-3924","position":9,"is_corresponding":false},{"id":563159,"name":"Eric Wu","orcid":"0000-0001-8315-3288","position":10,"is_corresponding":false},{"id":563160,"name":"Paweł Hottowy","orcid":"0000-0002-7592-2195","position":11,"is_corresponding":false},{"id":316888,"name":"Alexander Sher","orcid":"0000-0001-6655-6456","position":12,"is_corresponding":false},{"id":9450,"name":"A. M. Litke","orcid":"0000-0003-3973-3642","position":13,"is_corresponding":false},{"id":563966,"name":"Ruwan A. Silva","orcid":null,"position":14,"is_corresponding":false},{"id":248053,"name":"E. J. Chichilnisky","orcid":"0000-0002-5613-0248","position":15,"is_corresponding":false},{"id":563151,"name":"Sasidhar Madugula","orcid":"0000-0002-4519-5249","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T23:14:51.076430Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}