{"doi":"10.1101/2020.08.18.20166835","title":"SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study","abstract":"BACKGROUND: Children with SARS-CoV-2 infection typically have mild symptoms that do not require medical attention, leaving a gap in our understanding of the spectrum of illnesses that the virus causes in children. METHODS: We conducted a prospective cohort study of children and adolescents (<21 years of age) with a SARS-CoV-2-infected close contact. We collected nasopharyngeal or nasal swabs at enrollment and tested for SARS-CoV-2 using a real-time PCR assay. RESULTS: Of 382 children, 289 (76%) were SARS-CoV-2-infected. SARS-CoV-2-infected children were more likely to be Hispanic (p<0.0001), less likely to have a history of asthma (p=0.009), and more likely to have an infected sibling contact (p=0.0007) than uninfected children. Children ages 6-13 years were frequently asymptomatic (38%) and had respiratory symptoms less often than younger children (30% vs. 49%; p=0.008) or adolescents (30% vs. 59%; p<0.0001). Compared to children ages 6-13 years, adolescents more frequently reported influenza-like (61% vs. 39%; p=0.002), gastrointestinal (26% vs. 9%; p=0.003), and sensory symptoms (43% vs. 9%; p<0.0001), and had more prolonged illnesses [median (IQR) duration: 7 (4, 12) vs. 4 (3, 8) days; p=0.004]. Despite the age-related variability in symptoms, we found no differences in nasopharyngeal viral load by age or between symptomatic and asymptomatic children. CONCLUSIONS: Hispanic ethnicity and an infected sibling close contact are associated with increased SARS-CoV-2 infection risk among children, while a history of asthma is associated with decreased risk. Age-related differences in the clinical manifestations of SARS-CoV-2 infection must be considered when evaluating children for COVID-19 and in developing screening strategies for schools and childcare settings.","journal":"medRxiv","year":2020,"id":118712,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8291,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":322353,"name":"Sarah M. Heston","orcid":"0000-0001-6150-1149","position":1,"is_corresponding":false},{"id":327475,"name":"Hailey N. Chambers","orcid":null,"position":2,"is_corresponding":false},{"id":325724,"name":"Hannah Cunningham","orcid":"0009-0005-1263-3344","position":3,"is_corresponding":false},{"id":553069,"name":"Meghan J. Price","orcid":null,"position":4,"is_corresponding":false},{"id":553070,"name":"Liliana Suarez","orcid":null,"position":5,"is_corresponding":false},{"id":327476,"name":"Carter Crew","orcid":null,"position":6,"is_corresponding":false},{"id":288417,"name":"Shree Bose","orcid":"0000-0003-3350-0733","position":7,"is_corresponding":false},{"id":327477,"name":"Jhoanna N. Aquino","orcid":null,"position":8,"is_corresponding":false},{"id":327478,"name":"Stuart Carr","orcid":null,"position":9,"is_corresponding":false},{"id":325727,"name":"Shannon M. Griffin","orcid":"0000-0001-6043-7448","position":10,"is_corresponding":false},{"id":325728,"name":"Stephanie H. Smith","orcid":"0009-0006-0971-428X","position":11,"is_corresponding":false},{"id":322354,"name":"Kirsten Jenkins","orcid":"0000-0003-3814-0546","position":12,"is_corresponding":false},{"id":327479,"name":"Trevor S. Pfeiffer","orcid":null,"position":13,"is_corresponding":false},{"id":322434,"name":"Javier Rodriguez","orcid":"0000-0001-9608-5069","position":14,"is_corresponding":false},{"id":327480,"name":"C. Todd DeMarco","orcid":null,"position":15,"is_corresponding":false},{"id":327481,"name":"Nicole A. De Naeyer","orcid":null,"position":16,"is_corresponding":false},{"id":327482,"name":"Thaddeus C. Gurley","orcid":null,"position":17,"is_corresponding":false},{"id":327483,"name":"Raul Louzao","orcid":null,"position":18,"is_corresponding":false},{"id":325730,"name":"Coleen K. Cunningham","orcid":"0000-0002-7725-3052","position":19,"is_corresponding":false},{"id":325731,"name":"William J. Steinbach","orcid":"0000-0002-5446-1094","position":20,"is_corresponding":false},{"id":325732,"name":"Thomas N. Denny","orcid":"0000-0002-7364-8276","position":21,"is_corresponding":false},{"id":327484,"name":"Debra J. Lugo","orcid":null,"position":22,"is_corresponding":false},{"id":32982,"name":"M. Anthony Moody","orcid":null,"position":23,"is_corresponding":false},{"id":240902,"name":"Sallie R. Permar","orcid":"0000-0003-1438-4554","position":24,"is_corresponding":false},{"id":325733,"name":"Alexandre T. Rotta","orcid":"0000-0002-4406-2276","position":25,"is_corresponding":false},{"id":3909,"name":"Nicholas A. Turner","orcid":"0000-0003-0650-4894","position":26,"is_corresponding":false},{"id":325734,"name":"Emmanuel B. Walter","orcid":"0000-0001-6502-6736","position":27,"is_corresponding":false},{"id":33039,"name":"Christopher W. Woods","orcid":"0000-0001-7240-2453","position":28,"is_corresponding":false},{"id":322359,"name":"Matthew S. Kelly","orcid":"0000-0001-8819-2315","position":29,"is_corresponding":false},{"id":325723,"name":"Jillian H. Hurst","orcid":"0000-0001-5079-9920","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T23:14:03.409507Z","pmid":"32908992","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}