{"doi":"10.1101/2020.08.17.254466","title":"HDAC1 SUMOylation promotes Argonaute directed transcriptional silencing in <i>C. elegans</i>","abstract":"SUMMARY Eukaryotic cells use guided search to coordinately control dispersed genetic elements. The transitive effectors of these mechanisms, Argonaute proteins and their small-RNA co-factors, engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing. The small ubiquitin-like modifier (SUMO) has been shown to promote the induction and maintenance of silent chromatin (called heterochromatin) in yeast, plants, and animals. Here we show that Argonaute-directed transcriptional silencing in C. elegans requires SUMOylation of the type 1 histone deacetylase HDA-1. SUMOylation of HDA-1 promotes interactions with components of the nucleosome remodeling and deacetylase (NuRD) complex and with the nuclear Argonaute HRDE-1/WAGO-9. Our findings suggest how HDAC1 SUMOylation promotes the association of HDAC and other chromatin remodeling factors with a nuclear Argonaute in order to initiate de novo heterochromatin silencing.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":130709,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":583482,"name":"Yue‐He Ding","orcid":"0000-0003-0834-2761","position":1,"is_corresponding":false},{"id":583483,"name":"Gangming Zhang","orcid":"0000-0002-8488-2607","position":2,"is_corresponding":false},{"id":403133,"name":"Yonghong Yan","orcid":null,"position":3,"is_corresponding":false},{"id":492768,"name":"Darryl Conte","orcid":"0000-0002-1137-8901","position":4,"is_corresponding":false},{"id":583484,"name":"Meng‐Qiu Dong","orcid":"0000-0002-6094-1182","position":5,"is_corresponding":false},{"id":55773,"name":"Craig C. Mello","orcid":"0000-0001-9176-6551","position":6,"is_corresponding":false},{"id":583481,"name":"Heesun Kim","orcid":"0000-0001-7643-4516","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-18T23:15:56.698770Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}