{"doi":"10.1101/2020.08.16.20175596","title":"Quantitative mobility measures complement the MDS-UPDRS for characterization of Parkinson’s disease heterogeneity","abstract":"Abstract Introduction Emerging technologies show promise for enhanced characterization of Parkinson’s Disease (PD) motor manifestations. We evaluated quantitative mobility measures from a wearable device compared to the conventional motor assessment, the Movement Disorders Society-Unified PD Rating Scale part III (motor MDS-UPDRS). Methods We evaluated 176 subjects with PD (mean age 65, 65% male, 66% H&Y stage 2) at the time of routine clinic visits using the motor MDS-UPDRS and a structured 10-minute motor protocol, which included a 32-ft walk, Timed Up and Go (TUG), and standing posture with eyes closed, while wearing a body-fixed sensor (DynaPort MT, McRoberts BV). Regression models examined 12 quantitative mobility measures for associations with (i) motor MDS-UPDRS, (ii) motor subtype (tremor dominant vs. postural instability/gait difficulty), (iii) Montreal Cognitive Assessment (MoCA), and (iv) physical functioning disability (PROMIS-29). All analyses included age, gender, and disease duration as covariates. Models iii-iv were secondarily adjusted for motor MDS-UPDRS. Results Quantitative mobility measures from gait, TUG transitions, turning, and posture were significantly associated with motor MDS-UPDRS (7 of 12 measures, p< 0.05) and subtype (6 of 12 measures, p< 0.05). Compared with motor MDS-UPDRS, several quantitative mobility measures accounted for ∼1.5-fold increased variance in either cognition or physical functioning disability. Among minimally-impaired subjects within the bottom quartile of motor MDS-UPDRS, including subjects with normal gait exam, the measures captured substantial residual motor heterogeneity. Conclusion Clinic-based quantitative mobility assessments using a wearable sensor captured features of motor performance beyond those obtained with the motor MDS-UPDRS and may offer enhanced characterization of disease heterogeneity.","journal":"medRxiv","year":2020,"id":127211,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9232,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":232912,"name":"Carl Grant Mangleburg","orcid":"0000-0001-8854-195X","position":1,"is_corresponding":false},{"id":575747,"name":"Isabel Alfradique‐Dunham","orcid":"0000-0002-7723-2956","position":2,"is_corresponding":false},{"id":576529,"name":"Brittany Ripperger","orcid":null,"position":3,"is_corresponding":false},{"id":576530,"name":"Amanda Stillwell","orcid":null,"position":4,"is_corresponding":false},{"id":576531,"name":"Hiba Saade","orcid":null,"position":5,"is_corresponding":false},{"id":576532,"name":"Sindhu Rao","orcid":null,"position":6,"is_corresponding":false},{"id":576533,"name":"Oluwafunmiso Fagbongbe","orcid":null,"position":7,"is_corresponding":false},{"id":575748,"name":"Rainer von Coelln","orcid":"0000-0001-7651-2780","position":8,"is_corresponding":false},{"id":575749,"name":"Arjun Tarakad","orcid":"0000-0003-0409-2363","position":9,"is_corresponding":false},{"id":575750,"name":"Christine Hunter","orcid":"0000-0002-2583-2052","position":10,"is_corresponding":false},{"id":388725,"name":"Robert J. Dawe","orcid":"0000-0002-8266-9829","position":11,"is_corresponding":false},{"id":92189,"name":"Joseph Jankovic","orcid":"0000-0003-4129-3674","position":12,"is_corresponding":false},{"id":539246,"name":"Lisa M. Shulman","orcid":"0000-0002-1652-1201","position":13,"is_corresponding":false},{"id":388726,"name":"Aron S. Buchman","orcid":"0000-0002-6426-2742","position":14,"is_corresponding":false},{"id":232932,"name":"Joshua M. Shulman","orcid":"0000-0002-1835-1971","position":15,"is_corresponding":false},{"id":575746,"name":"Emily J. Hill","orcid":"0000-0002-5267-570X","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T23:15:30.930746Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}