{"doi":"10.1101/2020.08.13.247007","title":"CRISPR-Decryptr reveals cis-regulatory elements from noncoding perturbation screens","abstract":"Abstract Clustered Regularly Interspace Short Palindromic Repeats (CRISPR)-Cas9 genome editing methods provide the tools necessary to examine phenotypic impacts of targeted perturbations in high-throughput screens. While these technologies have the potential to reveal functional elements with direct therapeutic applications, statistical techniques to analyze noncoding screen data remain limited. We present CRISPR-Decryptr, a computational tool for the analysis of CRISPR noncoding screens. Our method leverages experimental design: accounting for multiple conditions, controls, and replicates to infer the regulatory landscape of noncoding genomic regions. We validate our method on a variety of mutagenesis, CRISPR activation, and CRISPR interference screens, extracting new insights from previously published data.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":130672,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":475,"name":"Tarmo Äijö","orcid":"0000-0002-3008-4634","position":1,"is_corresponding":false},{"id":325898,"name":"Mariano I. Gabitto","orcid":"0000-0001-6911-344X","position":2,"is_corresponding":false},{"id":90199,"name":"Nicholas Carriero","orcid":null,"position":3,"is_corresponding":false},{"id":32220,"name":"Neville E. Sanjana","orcid":"0000-0002-1504-0027","position":4,"is_corresponding":false},{"id":238127,"name":"Jane A. Skok","orcid":"0000-0002-4145-1516","position":5,"is_corresponding":false},{"id":476,"name":"Richard Bonneau","orcid":"0000-0003-4354-7906","position":6,"is_corresponding":false},{"id":583430,"name":"A. Rasmussen","orcid":"0000-0003-4529-1107","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-18T23:15:56.698770Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}