{"doi":"10.1101/2020.08.12.248120","title":"Deletion of the voltage-gated calcium channel, Ca <sub>V</sub> 1.3, causes deficits in motor performance and associative learning","abstract":"Abstract L-type voltage-gated calcium channels are important regulators of neuronal activity and are widely expressed throughout the brain. One of the major L-type voltage-gated calcium channel isoforms in the brain is Ca V 1.3. Mice lacking Ca V 1.3 are reported to have impairments in fear conditioning and depressive-like behaviors, which have been linked to Ca V 1.3 function in the hippocampus and amygdala. Genetic variation in Ca V 1.3 has been linked to a variety of psychiatric disorders, including autism and schizophrenia, which are associated with altered motor learning, associative learning, and social function. Here, we explored whether Ca V 1.3 plays a role in these behaviors. We found that Ca V 1.3 knockout mice have deficits in rotarod learning despite normal locomotor function. Deletion of Ca V 1.3 is also associated with impaired gait adaptation and associative learning on the Erasmus Ladder. We did not observe any impairments in Ca V 1.3 knockout mice on assays of anxiety-like, depression-like, or social preference behaviors. Our results suggest an important role for Ca V 1.3 in neural circuits involved in motor learning and concur with previous data showing its involvement in associative learning.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":130670,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9462,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":49075,"name":"Hsiang Wen","orcid":null,"position":1,"is_corresponding":false},{"id":583922,"name":"Bryn Myers","orcid":null,"position":2,"is_corresponding":false},{"id":583427,"name":"Ashley N. Plumb","orcid":"0000-0002-8566-4943","position":3,"is_corresponding":false},{"id":583428,"name":"K L Parker","orcid":"0000-0001-5759-7440","position":4,"is_corresponding":false},{"id":459189,"name":"Aislinn Williams","orcid":"0000-0002-8139-2303","position":5,"is_corresponding":false},{"id":583426,"name":"Marisol Lauffer","orcid":"0000-0001-9670-8131","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T23:15:56.698770Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}