{"doi":"10.1101/2020.08.07.242271","title":"SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease","abstract":"We determined the antigen binding activity of convalescent plasma units from 47 individuals with a history of non-severe COVID-19 using three clinical diagnostic serology assays (Beckman, DiaSorin, and Roche) with different SARS-CoV-2 targets. We compared these results with functional neutralization activity using a fluorescent reporter strain of SARS-CoV-2 in a microwell assay. This revealed positive correlations of varying strength (Spearman r = 0.37-0.52) between binding and neutralization. Donors age 48-75 had the highest neutralization activity. Units in the highest tertile of binding activity for each assay were enriched (75-82%) for those with the highest levels of neutralization.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":121280,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":341867,"name":"Joshua M. Thiede","orcid":"0000-0002-6603-281X","position":1,"is_corresponding":false},{"id":341868,"name":"William E. Matchett","orcid":"0000-0001-7515-2226","position":2,"is_corresponding":false},{"id":343245,"name":"Abigail R. Gress","orcid":null,"position":3,"is_corresponding":false},{"id":343246,"name":"Kathryn A. Pape","orcid":null,"position":4,"is_corresponding":false},{"id":318063,"name":"Marc K. Jenkins","orcid":"0000-0001-8009-7655","position":5,"is_corresponding":false},{"id":105316,"name":"Vineet D. Menachery","orcid":"0000-0001-8803-7606","position":6,"is_corresponding":false},{"id":266263,"name":"Ryan A. Langlois","orcid":"0000-0002-0515-571X","position":7,"is_corresponding":false},{"id":341870,"name":"Tyler D. Bold","orcid":"0000-0001-7360-6546","position":8,"is_corresponding":false},{"id":341866,"name":"Thomas J. Gniadek","orcid":"0000-0002-4092-9397","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-18T23:14:42.734024Z","pmid":"32817936","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}