{"doi":"10.1101/2020.08.07.20169862","title":"IgG antibody responses are preferential compared to IgM for use as serological markers for detecting recent exposure to <i>Plasmodium vivax</i> infection","abstract":"Abstract To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax . Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, IgM in addition to IgG antibody responses were assessed to a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.","journal":"medRxiv","year":2020,"id":127963,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":283138,"name":"Michael White","orcid":"0000-0002-7472-4138","position":1,"is_corresponding":false},{"id":340772,"name":"Jessica Brewster","orcid":null,"position":2,"is_corresponding":false},{"id":339353,"name":"Zoe Liu","orcid":"0000-0002-0269-0119","position":3,"is_corresponding":false},{"id":339352,"name":"Caitlin Bourke","orcid":"0000-0002-4466-6563","position":4,"is_corresponding":false},{"id":339354,"name":"Eizo Takashima","orcid":"0000-0001-9070-8499","position":5,"is_corresponding":false},{"id":77648,"name":"Matthias Harbers","orcid":"0000-0002-5613-7220","position":6,"is_corresponding":false},{"id":339356,"name":"Wai‐Hong Tham","orcid":"0000-0001-7950-8699","position":7,"is_corresponding":false},{"id":339357,"name":"Julie Healer","orcid":"0000-0001-8917-6237","position":8,"is_corresponding":false},{"id":323749,"name":"Chetan E. Chitnis","orcid":"0000-0002-8773-9865","position":9,"is_corresponding":false},{"id":3928,"name":"Wuelton Marcelo Monteiro","orcid":"0000-0002-0848-1940","position":10,"is_corresponding":false},{"id":3855,"name":"Marcus V. G. de Lacerda","orcid":"0000-0003-3374-9985","position":11,"is_corresponding":false},{"id":334155,"name":"Jetsumon Sattabongkot","orcid":"0000-0002-3938-4588","position":12,"is_corresponding":false},{"id":339355,"name":"Takafumi Tsuboi","orcid":"0000-0002-7415-1325","position":13,"is_corresponding":false},{"id":283141,"name":"Ivo Müeller","orcid":"0000-0001-6554-6889","position":14,"is_corresponding":false},{"id":339360,"name":"Rhea J. Longley","orcid":"0000-0002-4510-5602","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-18T23:15:34.966380Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}