{"doi":"10.1101/2020.08.07.20167130","title":"Natural Polymorphisms in <i>Mycobacterium tuberculosis</i> Conferring Resistance to Delamanid in Drug-naïve Patients","abstract":"ABSTRACT Mutations in the genes of the F 420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC , and fbiD , of Mycobacterium tuberculosis ( Mtb ) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For ten strains with mutations, we determined the minimum inhibitory concentration (MIC) of delamanid. We found one strain from a delamanid-naïve patient carrying the natural polymorphism Tyr29del ( ddn ) that was associated with a critical MIC to delamanid.","journal":"medRxiv","year":2020,"id":125277,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9586,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":571912,"name":"Rico Hoemke","orcid":null,"position":1,"is_corresponding":false},{"id":424026,"name":"Kathrin Zürcher","orcid":"0000-0002-7915-3194","position":2,"is_corresponding":false},{"id":506581,"name":"Peter Sander","orcid":"0000-0003-1581-0682","position":3,"is_corresponding":false},{"id":424033,"name":"Anchalee Avihingsanon","orcid":"0000-0003-3222-9611","position":4,"is_corresponding":false},{"id":507512,"name":"Jimena Collantes","orcid":null,"position":5,"is_corresponding":false},{"id":424024,"name":"Chloé Loiseau","orcid":"0000-0003-4889-2784","position":6,"is_corresponding":false},{"id":424027,"name":"Sònia Borrell","orcid":"0000-0001-6661-6957","position":7,"is_corresponding":false},{"id":425230,"name":"Miriam Reinhard","orcid":null,"position":8,"is_corresponding":false},{"id":266683,"name":"Robert J. Wilkinson","orcid":"0000-0002-2753-1800","position":9,"is_corresponding":false},{"id":61432,"name":"Marcel Yotebieng","orcid":"0000-0003-2110-2631","position":10,"is_corresponding":false},{"id":424029,"name":"Lukas Fenner","orcid":"0000-0003-3309-4835","position":11,"is_corresponding":false},{"id":108181,"name":"Erik C. Böttger","orcid":"0000-0002-2570-0121","position":12,"is_corresponding":false},{"id":424035,"name":"Sébastien Gagneux","orcid":"0000-0001-7783-9048","position":13,"is_corresponding":false},{"id":4469,"name":"Matthias Egger","orcid":"0000-0001-7462-5132","position":14,"is_corresponding":false},{"id":506582,"name":"Peter M. Keller","orcid":"0000-0002-2890-5384","position":15,"is_corresponding":false},{"id":506580,"name":"Martina L. Reichmuth","orcid":"0000-0001-9345-851X","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T23:15:15.482227Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}