{"doi":"10.1101/2020.08.06.20169367","title":"Dynamics of neutralizing antibody titers in the months after SARS-CoV-2 infection","abstract":"Abstract Most individuals infected with SARS-CoV-2 develop neutralizing antibodies that target the viral spike protein. Here we quantify how levels of these antibodies change in the months following SARS-CoV-2 infection by examining longitudinal samples collected between ~30 and 152 days post-symptom onset from a prospective cohort of 34 recovered individuals with asymptomatic, mild, or moderate-severe disease. Neutralizing antibody titers declined an average of about four-fold from one to four months post-symptom onset. This decline in neutralizing antibody titers was accompanied by a decline in total antibodies capable of binding the viral spike or its receptor-binding domain. Importantly, our data are consistent with the expected early immune response to viral infection, where an initial peak in antibody levels is followed by a decline to a lower plateau. Additional studies of long-lived B-cells and antibody titers over longer time frames are necessary to determine the durability of immunity to SARS-CoV-2.","journal":"medRxiv","year":2020,"id":118346,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":104,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106712,"name":"Adam S. Dingens","orcid":"0000-0001-9603-9409","position":1,"is_corresponding":false},{"id":106710,"name":"Rachel Eguia","orcid":"0000-0001-5772-1907","position":2,"is_corresponding":false},{"id":233068,"name":"Caitlin R. Wolf","orcid":"0000-0002-4883-1060","position":3,"is_corresponding":false},{"id":238909,"name":"Naomi Wilcox","orcid":null,"position":4,"is_corresponding":false},{"id":108419,"name":"Jennifer K. Logue","orcid":"0000-0002-7889-8960","position":5,"is_corresponding":false},{"id":236434,"name":"Kiel Shuey","orcid":"0000-0002-2525-1610","position":6,"is_corresponding":false},{"id":236435,"name":"Amanda M. Casto","orcid":"0000-0001-8332-8578","position":7,"is_corresponding":false},{"id":108912,"name":"Brooke Fiala","orcid":"0000-0003-0148-5268","position":8,"is_corresponding":false},{"id":108911,"name":"Samuel Wrenn","orcid":null,"position":9,"is_corresponding":false},{"id":225379,"name":"Deleah Pettie","orcid":"0000-0002-5477-7195","position":10,"is_corresponding":false},{"id":108915,"name":"Neil P. King","orcid":"0000-0002-2978-4692","position":11,"is_corresponding":false},{"id":103432,"name":"Helen Y. Chu","orcid":"0000-0001-8502-9600","position":12,"is_corresponding":false},{"id":106715,"name":"Jesse D. Bloom","orcid":"0000-0003-1267-3408","position":13,"is_corresponding":false},{"id":106711,"name":"Katharine H. D. Crawford","orcid":"0000-0002-6223-4019","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T23:13:58.531532Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}