{"doi":"10.1101/2020.08.05.20168971","title":"Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals","abstract":"Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role in the development of vaccines and antibody-based interventions. We report systemic and mucosal antibody responses in convalescent individuals who experienced varying disease severity. Robust antibody responses to diverse SARS-CoV-2 antigens and evidence of elevated responses to endemic CoV were observed among convalescent donors. SARS-CoV-2-specific IgA and IgG responses were often negatively correlated, particularly in mucosal samples, suggesting subject-intrinsic biases in isotype switching. Assessment of antibody-mediated effector functions revealed an inverse correlation between systemic and mucosal neutralization activity and site-dependent differences in the isotype of neutralizing antibodies. Serum neutralization correlated with systemic anti-SARS-CoV-2 IgG and IgM response magnitude, while mucosal neutralization was associated with nasal SARS-CoV-2-specific IgA. These findings begin to map how diverse Ab characteristics relate to Ab functions and outcomes of infection, informing public health assessment strategies and vaccine development efforts.","journal":"medRxiv","year":2020,"id":119732,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9487,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":291269,"name":"Andrew R. Crowley","orcid":"0000-0002-5011-5362","position":1,"is_corresponding":false},{"id":552589,"name":"Harini Natarajan","orcid":"0000-0002-9205-289X","position":2,"is_corresponding":false},{"id":552590,"name":"Shiwei Xu","orcid":"0000-0002-1520-2145","position":3,"is_corresponding":false},{"id":332543,"name":"Joshua A. Weiner","orcid":"0000-0003-1054-0628","position":4,"is_corresponding":false},{"id":392857,"name":"Jiwon Lee","orcid":"0000-0001-7835-3621","position":5,"is_corresponding":false},{"id":552591,"name":"Wendy Wieland‐Alter","orcid":"0000-0001-9356-8188","position":6,"is_corresponding":false},{"id":552592,"name":"Ruth I. Connor","orcid":"0000-0002-7477-9411","position":7,"is_corresponding":false},{"id":527420,"name":"Peter F. Wright","orcid":"0000-0003-1950-6928","position":8,"is_corresponding":false},{"id":291270,"name":"Margaret E. Ackerman","orcid":"0000-0002-4253-3476","position":9,"is_corresponding":false},{"id":553314,"name":"Savannah E. Butler","orcid":null,"position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-18T23:14:13.002105Z","pmid":"32793926","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}