{"doi":"10.1101/2020.07.30.20165241","title":"Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection","abstract":"The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra- patient heterogeneity of pulmonary virus infection. There was a spectrum of high and low virus cases that was associated with duration of disease and activation of interferon pathway genes. Using a digital spatial profiling platform, the virus corresponded to distinct spatial expression of interferon response genes and immune checkpoint genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.","journal":"medRxiv","year":2020,"id":118721,"datarank":0.5742962094733643,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":0.0,"self_endowment_contribution":0.5742962094733643,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237346,"name":"Azfar Neyaz","orcid":"0000-0001-5321-190X","position":1,"is_corresponding":false},{"id":230839,"name":"Annamária Szabolcs","orcid":"0000-0003-4951-9914","position":2,"is_corresponding":false},{"id":237347,"name":"Angela Shih","orcid":"0000-0002-8945-5997","position":3,"is_corresponding":false},{"id":3009,"name":"Jonathan Chen","orcid":"0000-0001-6074-9302","position":4,"is_corresponding":false},{"id":237348,"name":"Vishal Thapar","orcid":"0000-0002-8397-8279","position":5,"is_corresponding":false},{"id":59692,"name":"Linda T. 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