{"doi":"10.1101/2020.07.29.20162917","title":"Evidence favouring the efficacy of convalescent plasma for COVID-19 therapy","abstract":"To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials (RCT), 20 matched-control studies, two dose-response studies, and 96 case-reports or case series. Studies published between January 1, 2020 to January 16, 2021 were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of RCT and matched-control data demonstrated that COVID-19 patients transfused with convalescent plasma exhibited a lower mortality rate compared to patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized COVID-19 patients.","journal":"medRxiv","year":2020,"id":118404,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":89,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8366,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":512112,"name":"Stephen A. Klassen","orcid":"0000-0002-4560-8728","position":1,"is_corresponding":false},{"id":512111,"name":"Jonathon W. Senefeld","orcid":"0000-0001-8116-3538","position":2,"is_corresponding":false},{"id":287564,"name":"Patrick W. Johnson","orcid":"0000-0001-8365-1375","position":3,"is_corresponding":false},{"id":288520,"name":"Rickey E. Carter","orcid":"0000-0002-0818-273X","position":4,"is_corresponding":false},{"id":322917,"name":"Chad C. Wiggins","orcid":"0000-0002-6458-0142","position":5,"is_corresponding":false},{"id":227512,"name":"Shmuel Shoham","orcid":"0000-0001-7276-7786","position":6,"is_corresponding":false},{"id":504654,"name":"Brenda J. Grossman","orcid":"0000-0002-1500-8211","position":7,"is_corresponding":false},{"id":227341,"name":"Jeffrey P. Henderson","orcid":"0000-0003-1755-3202","position":8,"is_corresponding":false},{"id":235711,"name":"James M. Musser","orcid":"0000-0002-7765-4956","position":9,"is_corresponding":false},{"id":235689,"name":"Eric Salazar","orcid":"0000-0003-1961-3125","position":10,"is_corresponding":false},{"id":550562,"name":"William R. Hartman","orcid":"0000-0003-2118-7591","position":11,"is_corresponding":false},{"id":226728,"name":"Nicole M. Bouvier","orcid":"0000-0002-4530-2841","position":12,"is_corresponding":false},{"id":104928,"name":"Sean Liu","orcid":"0000-0002-3842-6838","position":13,"is_corresponding":false},{"id":504851,"name":"Liise-anne Pirofski","orcid":"0000-0002-7568-2961","position":14,"is_corresponding":false},{"id":322918,"name":"Sarah E. Baker","orcid":"0000-0001-9647-7660","position":15,"is_corresponding":false},{"id":550563,"name":"Noud van Helmond","orcid":"0000-0003-1395-4754","position":16,"is_corresponding":false},{"id":550564,"name":"R. Scott Wright","orcid":"0000-0002-0625-0444","position":17,"is_corresponding":false},{"id":248042,"name":"DeLisa Fairweather","orcid":"0000-0003-3093-1810","position":18,"is_corresponding":false},{"id":40577,"name":"Katelyn A. Bruno","orcid":"0000-0001-8980-6059","position":19,"is_corresponding":false},{"id":7713,"name":"Nigel Paneth","orcid":"0000-0002-0151-966X","position":20,"is_corresponding":false},{"id":107237,"name":"Arturo Casadevall","orcid":"0000-0002-9402-9167","position":21,"is_corresponding":false},{"id":7712,"name":"Michael J. Joyner","orcid":"0000-0002-7135-7643","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-18T23:13:58.531532Z","pmid":"33140056","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}