{"doi":"10.1101/2020.07.22.213959","title":"From people to <i>Panthera</i> : Natural SARS-CoV-2 infection in tigers and lions at the Bronx Zoo","abstract":"Abstract We describe the first cases of natural SARS-CoV-2 infection detected in animals in the United States. In March 2020, four tigers and three lions at the Bronx Zoo developed mild respiratory signs. SARS-CoV-2 RNA was detected by rRT-PCR in respiratory secretions and/or feces from all seven affected animals; viral RNA and/or antibodies were detected in their keepers. SARS-CoV-2 was isolated from respiratory secretions or feces from three affected animals; in situ hybridization co-localized viral RNA with cellular damage. Whole genome sequence and haplotype network analyses showed tigers and lions were infected with two different SARS-CoV-2 strains, suggesting independent viral introductions. The source of SARS-CoV-2 infection in the lions is unknown. Epidemiological data and genetic similarities between keeper and tiger viruses indicate human to animal transmission.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":118891,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9607,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":552352,"name":"Melissa Laverack","orcid":"0000-0003-3102-2088","position":1,"is_corresponding":false},{"id":552353,"name":"Leyi Wang","orcid":"0000-0001-5813-9505","position":2,"is_corresponding":false},{"id":499702,"name":"Mary Lea Killian","orcid":"0000-0002-8613-2009","position":3,"is_corresponding":false},{"id":552354,"name":"Leonardo C. 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