{"doi":"10.1101/2020.07.15.20131789","title":"SARS-CoV-2 Viral Load is Associated with Increased Disease Severity and Mortality","abstract":"ABSTRACT The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). We quantified SARS-CoV-2 viral load from participants with a diverse range of COVID-19 severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. SARS-CoV-2 plasma RNA was detected in 27% of hospitalized participants and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, higher prevalence of detectable SARS-CoV-2 plasma viral load was associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma viremia, were associated with increased risk of mortality. SARS-CoV-2 viral load may aid in the risk stratification of patients with COVID-19 and its role in disease pathogenesis should be further explored.","journal":"medRxiv","year":2020,"id":118391,"datarank":0.6814942173405006,"base_score":4.543294782270004,"endowment":4.543294782270004,"self_citation_contribution":0.6814942173405006,"citation_network_contribution":0.0,"self_endowment_contribution":0.6814942173405006,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":93,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":218316,"name":"James Regan","orcid":"0000-0003-0449-2295","position":1,"is_corresponding":false},{"id":218317,"name":"Kendyll Coxen","orcid":null,"position":2,"is_corresponding":false},{"id":218318,"name":"Heather Corry","orcid":"0009-0006-4902-5702","position":3,"is_corresponding":false},{"id":218319,"name":"Colline Wong","orcid":"0000-0002-7691-2722","position":4,"is_corresponding":false},{"id":218320,"name":"Alexandra Rosenthal","orcid":null,"position":5,"is_corresponding":false},{"id":218321,"name":"Daniel Worrall","orcid":"0000-0002-7760-9848","position":6,"is_corresponding":false},{"id":218322,"name":"Françoise Giguel","orcid":null,"position":7,"is_corresponding":false},{"id":108361,"name":"Alicja Piechocka‐Trocha","orcid":"0000-0002-1547-524X","position":8,"is_corresponding":false},{"id":106723,"name":"Caroline Atyeo","orcid":"0000-0002-7489-0232","position":9,"is_corresponding":false},{"id":106724,"name":"Stephanie Fischinger","orcid":"0000-0003-2307-3379","position":10,"is_corresponding":false},{"id":41038,"name":"Andrew T. 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