{"doi":"10.1101/2020.07.12.20151068","title":"Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19","abstract":"Clinical manifestations of COVID-19 caused by the novel coronavirus SARS-CoV-2 are associated with age. While children are largely spared from severe respiratory disease, they can present with a SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) similar to Kawasaki's disease. Here, we show distinct antibody (Ab) responses in children with MIS-C compared to adults with severe COVID-19 causing acute respiratory distress syndrome (ARDS), and those who recovered from mild disease. There was a reduced breadth and specificity of anti-SARS-CoV-2-specific antibodies in MIS-C patients compared to the COVID patient groups; MIS-C predominantly generated IgG Abs specific for the Spike (S) protein but not for the nucleocapsid (N) protein, while both COVID-19 cohorts had anti-S IgG, IgM and IgA Abs, as well as anti-N IgG Abs. Moreover, MIS-C patients had reduced neutralizing activity compared to COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children and adults who develop severe disease, with implications for optimizing treatments based on symptom and age.","journal":"medRxiv","year":2020,"id":118506,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":68,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9556,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":225921,"name":"Thomas J. 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Gray","orcid":"0000-0003-2796-5470","position":9,"is_corresponding":false},{"id":229311,"name":"Emma Idzikowski","orcid":null,"position":10,"is_corresponding":false},{"id":225930,"name":"Francesca T. Bovier","orcid":"0000-0003-3446-9619","position":11,"is_corresponding":false},{"id":225931,"name":"Julia Davis‐Porada","orcid":"0000-0001-9313-4590","position":12,"is_corresponding":false},{"id":229312,"name":"Rei Matsumoto","orcid":null,"position":13,"is_corresponding":false},{"id":229313,"name":"Maya M.L. 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