{"doi":"10.1101/2020.07.08.20147371","title":"D614G Spike Variant Does Not Alter IgG, IgM, or IgA Spike Seroassay Performance","abstract":"Emergence of a new variant of spike protein (D614G) with increased infectivity and transmissibility has prompted many to analyze the potential role of this variant in the SARS-CoV-2 pandemic. When a new variant emerges, there is a concern regarding whether an individual exposed to one variant of a virus will have cross-reactive immune memory to the second variant. Accordingly, we analyzed the serologic reactivity of D614 (original) and G614 variant spike proteins. We found that antibodies from a high-incidence population in New York City reacted both toward the original D614 spike and the G614 spike variant. These data suggest that patients who have been exposed to either SARS-CoV-2 variant have humoral immunity that can respond against both variants. This is an important finding both for SARS-CoV-2 disease biology and for potential antibody-based therapeutics.","journal":"medRxiv","year":2020,"id":119421,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":342131,"name":"Heather Kalish","orcid":"0000-0002-4848-2067","position":1,"is_corresponding":false},{"id":342132,"name":"Jennifer Hicks","orcid":"0000-0002-7380-1242","position":2,"is_corresponding":false},{"id":269417,"name":"Jennifer Mehalko","orcid":null,"position":3,"is_corresponding":false},{"id":267810,"name":"Matthew Drew","orcid":"0000-0002-3954-6671","position":4,"is_corresponding":false},{"id":233146,"name":"Matthew J. Memoli","orcid":"0000-0001-6393-5178","position":5,"is_corresponding":false},{"id":255126,"name":"Matthew D. Hall","orcid":"0000-0002-5073-442X","position":6,"is_corresponding":false},{"id":267809,"name":"Dominic Esposito","orcid":"0000-0002-9987-1687","position":7,"is_corresponding":false},{"id":238245,"name":"Kaitlyn Sadtler","orcid":"0000-0003-2587-8330","position":8,"is_corresponding":false},{"id":287620,"name":"Carleen Klumpp‐Thomas","orcid":"0000-0002-6646-6132","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-18T23:14:08.313144Z","pmid":"32676618","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}