{"doi":"10.1101/2020.07.08.194555","title":"Cortical Localization of the Sensory-Motor Transformation in a Whisker Detection Task in Mice","abstract":"Abstract Responding to a stimulus requires transforming an internal sensory representation into an internal motor representation. Where and how this sensory-motor transformation occurs is a matter of vigorous debate. Here, we trained mice in a whisker detection go/no-go task in which they learned to respond (lick) following a transient whisker deflection. Using single unit recordings, we quantified sensory-, motor- and choice-related activities in whisker primary somatosensory cortex (S1), whisker primary motor cortex (wMC) and anterior lateral motor cortex (ALM). Based on the criteria of having both strong sensory and motor representations and early choice probability, we identify whisker motor cortex as the cortical region most directly related to the sensory-motor transformation. Our data support a model of sensory amplification occurring between S1 and wMC, sensory-motor transformation occurring within wMC, and propagation of a motor command occurring between wMC and ALM.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":125148,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":570872,"name":"Zhaoran Zhang","orcid":"0000-0002-4192-4088","position":1,"is_corresponding":false},{"id":471704,"name":"Edward Zagha","orcid":"0000-0001-5892-3746","position":2,"is_corresponding":false},{"id":480840,"name":"Behzad Zareian","orcid":"0000-0002-1128-2504","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:15:15.482227Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}