{"doi":"10.1101/2020.07.08.193433","title":"Fast and sensitive diffuse correlation spectroscopy with highly parallelized single photon detection","abstract":"Diffuse correlation spectroscopy (DCS) is a well-established method that measures rapid changes in scattered coherent light to identify blood flow and functional dynamics within tissue. While its sensitivity to minute scatterer displacements leads to a number of unique advantages, conventional DCS systems become photon-limited when attempting to probe deep into tissue, which leads to long measurement windows (∼1 sec). Here, we present a high-sensitivity DCS system with 1024 parallel detection channels integrated within a single-photon avalanche diode (SPAD) array, and demonstrate the ability to detect mm-scale perturbations up to 1 cm deep within a tissue-like phantom at up to 33 Hz sampling rate. We also show that this highly parallelized strategy can measure the human pulse at high fidelity and detect behaviorally-induced physiological variations from above the human prefrontal cortex. By greatly improving detection sensitivity and speed, highly parallelized DCS opens up new experiments for high-speed biological signal measurement.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":122195,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9574,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":304357,"name":"Ruobing Qian","orcid":"0000-0001-8465-683X","position":1,"is_corresponding":false},{"id":562991,"name":"Shiqi Xu","orcid":"0000-0002-8450-9001","position":2,"is_corresponding":false},{"id":562992,"name":"Pavan Chandra Konda","orcid":"0000-0001-7119-1949","position":3,"is_corresponding":false},{"id":562993,"name":"Mark Harfouche","orcid":"0000-0002-4657-4603","position":4,"is_corresponding":false},{"id":562994,"name":"Dawid Borycki","orcid":"0000-0002-1235-889X","position":5,"is_corresponding":false},{"id":562995,"name":"Joakim Jönsson","orcid":"0000-0003-2670-0366","position":6,"is_corresponding":false},{"id":562996,"name":"Edouard Berrocal","orcid":"0000-0003-2835-812X","position":7,"is_corresponding":false},{"id":562997,"name":"Colin Cooke","orcid":"0000-0003-1279-6061","position":8,"is_corresponding":false},{"id":562998,"name":"Haoqian Wang","orcid":"0000-0003-2792-8469","position":9,"is_corresponding":false},{"id":292945,"name":"Qionghai Dai","orcid":"0000-0001-7043-3061","position":10,"is_corresponding":false},{"id":257433,"name":"Roarke Horstmeyer","orcid":"0000-0002-2480-9141","position":11,"is_corresponding":false},{"id":562990,"name":"Wenhui Liu","orcid":"0000-0003-1837-9031","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:14:51.076430Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}