{"doi":"10.1101/2020.07.01.20144436","title":"“Injury-Prone”: Peripheral nerve injuries associated with prone positioning for COVID-19-related acute respiratory distress syndrome","abstract":"Abstract Patients with Coronavirus disease 2019 (COVID-19) who require invasive mechanical ventilation frequently meet the acute respiratory distress syndrome (ARDS) diagnostic criteria. Hospitals based in the United States have been incorporating prone positioning (PP) into the COVID-19-related ARDS treatment plan at a higher rate than normal. Here, we describe 11 patients admitted to a single inpatient rehabilitation hospital who were subsequently diagnosed with acquired focal/multifocal peripheral nerve injury (PNI) in association with the use of PP for COVID-19-related ARDS. The reason for the high rate of PNI associated with PP in COVID-19 ARDS is likely multifactorial, but may include an underlying state of hyperinflammation and hypercoagulability already linked to other the neurological sequelae of COVID-19. Physicians must be aware of this elevated susceptibility to PNI in severe COVID-19 and refined standard PP protocols in order to reduce the risk.","journal":"medRxiv","year":2020,"id":119631,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.943,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":555462,"name":"Alexis R. Wolfe","orcid":"0000-0001-9321-892X","position":1,"is_corresponding":false},{"id":556512,"name":"Rachna Soriano","orcid":null,"position":2,"is_corresponding":false},{"id":555463,"name":"Leslie Rydberg","orcid":"0000-0001-5817-4861","position":3,"is_corresponding":false},{"id":555464,"name":"Lisa F. Wolfe","orcid":"0000-0001-9044-4147","position":4,"is_corresponding":false},{"id":555465,"name":"Swati Deshmukh","orcid":"0000-0003-3537-8743","position":5,"is_corresponding":false},{"id":555466,"name":"Jason H. Ko","orcid":"0000-0002-3360-552X","position":6,"is_corresponding":false},{"id":556513,"name":"Ryan Nussbaum","orcid":null,"position":7,"is_corresponding":false},{"id":555467,"name":"Prakash Jayabalan","orcid":"0000-0002-0369-2896","position":8,"is_corresponding":false},{"id":266698,"name":"James M. Walter","orcid":"0000-0001-7428-3101","position":9,"is_corresponding":false},{"id":236109,"name":"Colin K. Franz","orcid":"0000-0003-4546-8638","position":10,"is_corresponding":false},{"id":555461,"name":"George R. Malik","orcid":"0000-0002-6738-2512","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-18T23:14:13.002105Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}