{"doi":"10.1101/2020.06.26.117010","title":"BATF3-dependent induction of IL-27 in B cells bridges the innate and adaptive stages of the antibody response","abstract":"Abstract B cells are exposed to innate and T cell stimuli during the antibody response, although whether and how they functionally integrate such signals are unclear. Here we have identified IL-27 as the cytokine specifically produced by murine B cells upon sequential stimulation by TLR ligands and then CD154 and IL-21, the hallmark factors of T follicular helper cells, and during the T-dependent antibody response to a conjugated hapten or virus infection. B-cell Il27p28 transcription is concomitant with increased locus accessibility and depends on newly induced BATF3 transcription factor. IL-27-producing B cells are inefficient in antibody secretion, but cooperate with IFNγ to promote proliferation, survival, class-switching and plasma cell differentiation of CD40-activated B cells, leading to optimal IgG2a and IgG1 responses. Overall, IL-27-producing B cells function as “helper” B cells that integrate the innate and adaptive stages of the antibody response. One-sentence summary B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":123833,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":567342,"name":"Rui Wang","orcid":"0000-0002-5305-3283","position":1,"is_corresponding":false},{"id":567343,"name":"Jingwei Wang","orcid":"0000-0002-7408-8362","position":2,"is_corresponding":false},{"id":567344,"name":"Shuai Wu","orcid":"0000-0003-1818-0831","position":3,"is_corresponding":false},{"id":428316,"name":"María E. Fernández","orcid":"0000-0002-4820-821X","position":4,"is_corresponding":false},{"id":567345,"name":"Carlos Eduardo Rivera","orcid":"0000-0001-9052-557X","position":5,"is_corresponding":false},{"id":567346,"name":"Christian Cervantes","orcid":"0000-0002-4784-3879","position":6,"is_corresponding":false},{"id":231699,"name":"Justin B. Moroney","orcid":"0000-0002-3656-1892","position":7,"is_corresponding":false},{"id":567347,"name":"Xiao-Dong Li","orcid":"0000-0002-4349-6996","position":8,"is_corresponding":false},{"id":256588,"name":"Nu Zhang","orcid":"0000-0001-9695-210X","position":9,"is_corresponding":false},{"id":231705,"name":"Hong Zan","orcid":"0000-0002-2873-7034","position":10,"is_corresponding":false},{"id":230204,"name":"Xiangzhi Meng","orcid":"0000-0002-3828-5609","position":11,"is_corresponding":false},{"id":567348,"name":"Fushun Zhang","orcid":"0000-0002-0696-8907","position":12,"is_corresponding":false},{"id":32677,"name":"Siyuan Zheng","orcid":"0000-0002-1031-9424","position":13,"is_corresponding":false},{"id":238480,"name":"Yidong Chen","orcid":"0000-0001-6806-2185","position":14,"is_corresponding":false},{"id":567349,"name":"Zhinan Yin","orcid":"0000-0001-6524-8777","position":15,"is_corresponding":false},{"id":351178,"name":"Ross M. Kedl","orcid":"0000-0002-9065-7895","position":16,"is_corresponding":false},{"id":278889,"name":"Booki Min","orcid":"0000-0002-2151-9413","position":17,"is_corresponding":false},{"id":305888,"name":"Christopher A. Hunter","orcid":"0000-0003-3092-1428","position":18,"is_corresponding":false},{"id":230207,"name":"Yan Xiang","orcid":"0000-0002-7633-1629","position":19,"is_corresponding":false},{"id":231706,"name":"Paolo Casali","orcid":"0000-0002-8982-5177","position":20,"is_corresponding":false},{"id":379113,"name":"Zhenming Xu","orcid":"0000-0002-5822-0570","position":21,"is_corresponding":false},{"id":567341,"name":"Hui Yan","orcid":"0000-0002-6990-2526","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T23:15:03.403566Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}