{"doi":"10.1101/2020.06.22.164475","title":"<i>C. elegans</i> methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor","abstract":"Vitamin B12 is an essential micronutrient that functions in two metabolic pathways: the canonical propionate breakdown pathway and the methionine/S-adenosylmethionine (Met/SAM) cycle. In Caenorhabditis elegans , low vitamin B12, or genetic perturbation of the canonical propionate breakdown pathway results in propionate accumulation and the transcriptional activation of a propionate shunt pathway. This propionate-dependent mechanism requires nhr-10 and is referred to as “B12-mechanism-I”. Here, we report that vitamin B12 represses the expression of Met/SAM cycle genes by a propionate-independent mechanism we refer to as “B12-mechanism-II”. This mechanism is activated by perturbations in the Met/SAM cycle, genetically or due to low dietary vitamin B12. B12-mechanism-II requires nhr-114 to activate Met/SAM cycle gene expression, the vitamin B12 transporter, pmp-5 , and adjust influx and efflux of the cycle by activating msra-1 and repressing cbs-1 , respectively. Taken together, Met/SAM cycle activity is sensed and transcriptionally adjusted to be in a tight metabolic regime.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":123798,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":281158,"name":"Melissa Walker","orcid":"0000-0001-6266-1638","position":1,"is_corresponding":false},{"id":305726,"name":"Olga Ponomarova","orcid":"0000-0001-6331-9949","position":2,"is_corresponding":false},{"id":305727,"name":"Hefei Zhang","orcid":"0000-0002-5187-7166","position":3,"is_corresponding":false},{"id":305728,"name":"Xuhang Li","orcid":"0000-0001-6071-9605","position":4,"is_corresponding":false},{"id":305729,"name":"Gregory Minevich","orcid":"0000-0002-7115-4416","position":5,"is_corresponding":false},{"id":305730,"name":"Albertha J.M. Walhout","orcid":"0000-0001-5587-3608","position":6,"is_corresponding":false},{"id":305725,"name":"Gabrielle E. Giese","orcid":"0000-0002-9338-2049","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T23:15:03.403566Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}