{"doi":"10.1101/2020.06.17.158394","title":"Structural mimicry confers robustness in the cyanobacterial circadian clock","abstract":"Abstract The histidine kinase SasA enhances robustness of circadian rhythms in the cyanobacterium S. elongatus by temporally controlling expression of the core clock components, kaiB and kaiC . Here we show that SasA also engages directly with KaiB and KaiC proteins to regulate the period and enhance robustness of the reconstituted circadian oscillator in vitro , particularly under limiting concentrations of KaiB. In contrast to its role regulating gene expression, oscillator function does not require SasA kinase activity; rather, SasA uses structural mimicry to cooperatively recruit the rare, fold-switched conformation of KaiB to the KaiC hexamer to form the nighttime repressive complex. Cooperativity gives way to competition with increasing concentrations of SasA to define a dynamic window by which SasA directly modulates clock robustness. One Sentence Summary SasA controls the assembly of clock protein complexes through a balance of cooperative and competitive interactions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":122847,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":564738,"name":"Jeffrey A. Swan","orcid":"0000-0002-4487-328X","position":1,"is_corresponding":false},{"id":565447,"name":"Joseph G. Palacios","orcid":null,"position":2,"is_corresponding":false},{"id":564739,"name":"Cigdem Sancar","orcid":"0000-0002-7242-8757","position":3,"is_corresponding":false},{"id":564740,"name":"Dustin C. Ernst","orcid":"0000-0001-8762-960X","position":4,"is_corresponding":false},{"id":565448,"name":"Rebecca K. Spangler","orcid":null,"position":5,"is_corresponding":false},{"id":564741,"name":"Clive R. Bagshaw","orcid":"0000-0002-5396-153X","position":6,"is_corresponding":false},{"id":285738,"name":"Sarvind Tripathi","orcid":"0000-0002-6959-0577","position":7,"is_corresponding":false},{"id":346069,"name":"Priya Crosby","orcid":"0000-0002-7532-7708","position":8,"is_corresponding":false},{"id":272270,"name":"Susan S. Golden","orcid":"0000-0002-4264-7019","position":9,"is_corresponding":false},{"id":285740,"name":"Carrie L. Partch","orcid":"0000-0002-4677-2861","position":10,"is_corresponding":false},{"id":378220,"name":"Andy LiWang","orcid":"0000-0003-4741-6946","position":11,"is_corresponding":false},{"id":378219,"name":"Joel Heisler","orcid":"0000-0002-2703-3035","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-18T23:14:55.385653Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}