{"doi":"10.1101/2020.06.17.156943","title":"Chromatin potential identified by shared single cell profiling of RNA and chromatin","abstract":"<h4>Summary</h4> Cell differentiation and function are regulated across multiple layers of gene regulation, including the modulation of gene expression by changes in chromatin accessibility. However, differentiation is an asynchronous process precluding a temporal understanding of the regulatory events leading to cell fate commitment. Here, we developed SHARE-seq, a highly scalable approach for measurement of chromatin accessibility and gene expression within the same single cell. Using 34,774 joint profiles from mouse skin, we develop a computational strategy to identify cis- regulatory interactions and define Domains of Regulatory Chromatin (DORCs), which significantly overlap with super-enhancers. We show that during lineage commitment, chromatin accessibility at DORCs precedes gene expression, suggesting changes in chromatin accessibility may prime cells for lineage commitment. We therefore develop a computational strategy (chromatin potential) to quantify chromatin lineage-priming and predict cell fate outcomes. Together, SHARE-seq provides an extensible platform to study regulatory circuitry across diverse cells within tissues.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":1575,"datarank":4.741092208707258,"base_score":4.836281906951478,"endowment":4.836281906951478,"self_citation_contribution":0.7254422860427218,"citation_network_contribution":4.015649922664536,"self_endowment_contribution":0.7254422860427218,"citer_contribution":4.015649922664536,"corpus_percentile":null,"corpus_rank":null,"citation_count":125,"citer_count":115,"citers_with_citation_signal":107,"citers_with_endowment":107,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.053,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-06-18","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":7638,"name":"Bing Zhang","orcid":"0000-0001-8676-2425","position":1,"is_corresponding":false},{"id":7641,"name":"Zachary Chiang","orcid":"0000-0001-6578-2021","position":3,"is_corresponding":false},{"id":534,"name":"Yan Hu","orcid":"0000-0003-0586-6527","position":4,"is_corresponding":false},{"id":7642,"name":"Jiarui Ding","orcid":"0000-0003-3670-7764","position":5,"is_corresponding":false},{"id":7643,"name":"Alison Brack","orcid":"0000-0002-4401-6501","position":6,"is_corresponding":false},{"id":7644,"name":"Vinay K. Kartha","orcid":"0000-0002-2160-2196","position":7,"is_corresponding":false},{"id":7645,"name":"Travis Law","orcid":"0000-0002-7399-3299","position":8,"is_corresponding":false},{"id":3031,"name":"Caleb A. Lareau","orcid":"0000-0003-4179-4807","position":9,"is_corresponding":false},{"id":7647,"name":"Ya-Chieh Hsu","orcid":null,"position":10,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":11,"is_corresponding":false},{"id":3630,"name":"Jason D. Buenrostro","orcid":"0000-0001-9958-3987","position":12,"is_corresponding":false},{"id":7639,"name":"Lindsay M. LaFave","orcid":"0000-0002-5203-4961","position":13,"is_corresponding":false},{"id":18192,"name":"Ya‐Chieh Hsu","orcid":"0000-0002-0178-7373","position":14,"is_corresponding":false},{"id":3622,"name":"Sai Ma","orcid":"0000-0002-9785-7929","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}