{"doi":"10.1101/2020.06.15.153387","title":"The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection","abstract":"Many efforts to design and screen therapeutics for severe acute respiratory syndrome coronavirus (SARS-CoV-2) have focused on inhibiting viral cell entry by disrupting ACE2 binding with the SARS-CoV-2 spike protein. This work focuses on inhibiting SARS-CoV-2 entry through a hypothesized α5β1 integrin-based mechanism, and indicates that inhibiting the spike protein interaction with α5β1 integrin (+/- ACE2), and the interaction between α5β1 integrin and ACE2 using a molecule ATN-161 represents a promising approach to treat COVID-19.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119553,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":291398,"name":"Naoki Iwanaga","orcid":"0000-0002-0680-390X","position":1,"is_corresponding":false},{"id":291399,"name":"Prem P. Chapagain","orcid":"0000-0002-0999-4975","position":2,"is_corresponding":false},{"id":291400,"name":"Wenshu Zheng","orcid":"0000-0001-6726-1326","position":3,"is_corresponding":false},{"id":218444,"name":"Chad J. Roy","orcid":"0000-0002-1710-6974","position":4,"is_corresponding":false},{"id":291401,"name":"Ye Hu","orcid":"0000-0001-7255-5409","position":5,"is_corresponding":false},{"id":246970,"name":"Jay K. Kolls","orcid":"0000-0001-5151-6304","position":6,"is_corresponding":false},{"id":291402,"name":"Gregory Bix","orcid":"0000-0002-8969-9553","position":7,"is_corresponding":false},{"id":259610,"name":"Brandon J. Beddingfield","orcid":"0000-0002-9438-1304","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T23:14:08.313144Z","pmid":"32587959","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}