{"doi":"10.1101/2020.06.12.20129858","title":"Genetic determinants of daytime napping and effects on cardiometabolic health","abstract":"Abstract Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remains unclear. Here, we performed a genome-wide association study of self-reported daytime napping in the UK Biobank ( n =452,633) and identified 123 loci of which 60 replicated in 23andMe research participants ( n =541,333). Findings included missense variants in established drug targets ( HCRTR1, HCRTR2 ), genes with roles in arousal ( TRPC6, PNOC ), and genes suggesting an obesity-hypersomnolence pathway ( PNOC, PATJ ). Signals were concordant with accelerometer-measured daytime inactivity duration and 33 signals colocalized with signals for other sleep phenotypes. Cluster analysis identified 3 clusters suggesting distinct nap-promoting mechanisms with heterogeneous associations with cardiometabolic outcomes. Mendelian randomization showed potential causal links between more frequent daytime napping and higher systolic blood pressure, diastolic blood pressure, and waist circumference.","journal":"medRxiv","year":2020,"id":119635,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9092,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":302169,"name":"Iyas Daghlas","orcid":"0000-0001-8735-284X","position":1,"is_corresponding":false},{"id":525138,"name":"Jacqueline M. Lane","orcid":"0000-0001-6101-2855","position":2,"is_corresponding":false},{"id":555475,"name":"Yunru Huang","orcid":"0000-0002-8834-8292","position":3,"is_corresponding":false},{"id":7372,"name":"Miriam S. Udler","orcid":"0000-0003-3824-9162","position":4,"is_corresponding":false},{"id":17003,"name":"Heming Wang","orcid":"0000-0002-1486-7495","position":5,"is_corresponding":false},{"id":555476,"name":"Hanna M. Ollila","orcid":"0000-0002-5302-6429","position":6,"is_corresponding":false},{"id":497603,"name":"Samuel E. Jones","orcid":"0000-0003-0153-922X","position":7,"is_corresponding":false},{"id":418507,"name":"Jaegil Kim","orcid":"0000-0001-8091-095X","position":8,"is_corresponding":false},{"id":345045,"name":"Andrew R. Wood","orcid":"0000-0003-1726-948X","position":9,"is_corresponding":false},{"id":22004,"name":"Michael N. Weedon","orcid":"0000-0002-6174-6135","position":10,"is_corresponding":false},{"id":24680,"name":"Stella Aslibekyan","orcid":null,"position":11,"is_corresponding":false},{"id":249990,"name":"Marta Garaulet","orcid":"0000-0002-4066-3509","position":12,"is_corresponding":false},{"id":249993,"name":"Richa Saxena","orcid":"0000-0003-2233-1065","position":13,"is_corresponding":false},{"id":263055,"name":"Hassan S. Dashti","orcid":"0000-0002-1650-679X","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":null,"created_at":"2026-07-18T23:14:13.002105Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}