{"doi":"10.1101/2020.06.10.145144","title":"Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2","abstract":"We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies. Here we assessed the prophylactic/therapeutic efficacy of hydroxychloroquine (HCQ), a drug of interest for COVID-19 management, in two animal models. When used for prophylaxis or treatment neither the standard human malaria dose (6.5 mg/kg) nor a high dose (50 mg/kg) of HCQ had any beneficial effect on clinical disease or SARS-CoV-2 kinetics (replication/shedding) in the Syrian hamster disease model. Similarly, HCQ prophylaxis/treatment (6.5 mg/kg) did not significantly benefit clinical outcome nor reduce SARS-CoV-2 replication/shedding in the upper and lower respiratory tract in the rhesus macaque disease model. In conclusion, our preclinical animal studies do not support the use of HCQ in prophylaxis/treatment of COVID-19.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":118766,"datarank":2.0691202879814594,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":1.504940270627425,"self_endowment_contribution":0.5641800173540344,"citer_contribution":1.504940270627425,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":40,"citers_with_citation_signal":33,"citers_with_endowment":33,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237976,"name":"Michael A. Jarvis","orcid":"0000-0002-0124-4061","position":1,"is_corresponding":false},{"id":107169,"name":"Friederike Feldmann","orcid":"0000-0002-1363-1077","position":2,"is_corresponding":false},{"id":108651,"name":"Benjamin Schwarz","orcid":"0000-0002-5894-953X","position":3,"is_corresponding":false},{"id":107174,"name":"Atsushi Okumura","orcid":"0000-0002-7779-3059","position":4,"is_corresponding":false},{"id":107189,"name":"Jamie Lovaglio","orcid":"0000-0002-7567-446X","position":5,"is_corresponding":false},{"id":107192,"name":"Greg Saturday","orcid":"0000-0002-0803-6177","position":6,"is_corresponding":false},{"id":107190,"name":"Patrick W. Hanley","orcid":"0000-0003-2300-1818","position":7,"is_corresponding":false},{"id":107175,"name":"Kimberly Meade‐White","orcid":"0000-0003-0503-8174","position":8,"is_corresponding":false},{"id":107181,"name":"Brandi N. Williamson","orcid":"0000-0002-9524-4395","position":9,"is_corresponding":false},{"id":237972,"name":"Frederick Hansen","orcid":"0000-0003-3890-1915","position":10,"is_corresponding":false},{"id":107176,"name":"Lizzette Pérez-Pérez","orcid":"0000-0001-5881-4363","position":11,"is_corresponding":false},{"id":239425,"name":"Shanna Leventhal","orcid":null,"position":12,"is_corresponding":false},{"id":552046,"name":"Tsing-Lee Tang-Huau","orcid":"0000-0002-3647-5855","position":13,"is_corresponding":false},{"id":105609,"name":"Martha Nason","orcid":"0000-0002-0110-881X","position":14,"is_corresponding":false},{"id":108408,"name":"Julie Callison","orcid":null,"position":15,"is_corresponding":false},{"id":274878,"name":"Elaine Haddock","orcid":"0000-0002-8260-227X","position":16,"is_corresponding":false},{"id":107191,"name":"Dana Scott","orcid":"0000-0002-7344-9402","position":17,"is_corresponding":false},{"id":337613,"name":"Graham Sewell","orcid":"0000-0001-8856-3980","position":18,"is_corresponding":false},{"id":245763,"name":"Catharine M. Bosio","orcid":"0000-0002-7332-9611","position":19,"is_corresponding":false},{"id":238504,"name":"David W. Hawman","orcid":"0000-0001-8233-8176","position":20,"is_corresponding":false},{"id":106696,"name":"Emmie de Wit","orcid":"0000-0002-9763-7758","position":21,"is_corresponding":false},{"id":107426,"name":"Heinz Feldmann","orcid":"0000-0001-9448-8227","position":22,"is_corresponding":false},{"id":237970,"name":"Kyle Rosenke","orcid":"0000-0001-8101-4348","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:14:03.409507Z","pmid":"32577633","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}