{"doi":"10.1101/2020.06.08.141267","title":"Structural basis of a public antibody response to SARS-CoV-2","abstract":"Molecular-level understanding of human neutralizing antibody responses to SARS-CoV-2 could accelerate vaccine design and facilitate drug discovery. We analyzed 294 SARS-CoV-2 antibodies and found that IGHV3-53 is the most frequently used IGHV gene for targeting the receptor binding domain (RBD) of the spike (S) protein. We determined crystal structures of two IGHV3-53 neutralizing antibodies +/- Fab CR3022 ranging from 2.33 to 3.11 Å resolution. The germline-encoded residues of IGHV3-53 dominate binding to the ACE2 binding site epitope with no overlap with the CR3022 epitope. Moreover, IGHV3-53 is used in combination with a very short CDR H3 and different light chains. Overall, IGHV3-53 represents a versatile public VH in neutralizing SARS-CoV-2 antibodies, where their specific germline features and minimal affinity maturation provide important insights for vaccine design and assessing outcomes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119190,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":108970,"name":"Hejun Liu","orcid":null,"position":1,"is_corresponding":false},{"id":105424,"name":"Nicholas C. Wu","orcid":"0000-0002-9078-6697","position":2,"is_corresponding":false},{"id":105426,"name":"Chang‐Chun D. Lee","orcid":"0000-0002-5470-2484","position":3,"is_corresponding":false},{"id":105425,"name":"Xueyong Zhu","orcid":"0000-0002-6021-3740","position":4,"is_corresponding":false},{"id":108971,"name":"Fangzhu Zhao","orcid":"0000-0002-3172-1340","position":5,"is_corresponding":false},{"id":108972,"name":"Deli Huang","orcid":"0000-0002-6989-639X","position":6,"is_corresponding":false},{"id":108973,"name":"Wenli Yu","orcid":"0000-0002-4025-2646","position":7,"is_corresponding":false},{"id":108974,"name":"Yuanzi Hua","orcid":null,"position":8,"is_corresponding":false},{"id":108975,"name":"Henry J. Tien","orcid":"0000-0001-7584-5989","position":9,"is_corresponding":false},{"id":108976,"name":"Thomas F. Rogers","orcid":"0000-0001-9756-327X","position":10,"is_corresponding":false},{"id":108977,"name":"Elise Landais","orcid":"0000-0002-8183-5565","position":11,"is_corresponding":false},{"id":108978,"name":"Devin Sok","orcid":"0000-0002-9354-1740","position":12,"is_corresponding":false},{"id":108979,"name":"Joseph G. Jardine","orcid":"0000-0001-8951-1074","position":13,"is_corresponding":false},{"id":108980,"name":"Dennis R. Burton","orcid":"0000-0001-6711-9864","position":14,"is_corresponding":false},{"id":105430,"name":"Ian A. Wilson","orcid":"0000-0002-6469-2419","position":15,"is_corresponding":false},{"id":105423,"name":"Meng Yuan","orcid":"0000-0001-9754-4503","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:14:08.313144Z","pmid":"32577642","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}